caa a22 4500 445334282 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-010-1535-9 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1535-9 Outcome After Laparoscopic Radiofrequency Ablation of Technically Resectable Colorectal Liver Metastases [Elektronische Daten] [Chet Hammill, Kevin Billingsley, Maria Cassera, Ronald Wolf, Michael Ujiki, Paul Hansen] Background: There continues to be controversy surrounding the appropriate use of radiofrequency ablation (RFA) for the treatment of colorectal liver metastases (CRLM). This study analyzes outcomes data of CRLM patients who underwent laparoscopic RFA. Outcomes of patients determined to be technically resectable were compared to patients with unresectable disease. Methods: Data from all patients with CRLM who underwent laparoscopic RFA between 1996 and 2006 were retrospectively reviewed. A blinded independent hepatobiliary-trained surgical oncologist reviewed preoperative diagnostic imaging studies to determine resectability. Outcomes data for patients with disease deemed anatomically resectable and unresectable were analyzed and compared. Survival was calculated by the Kaplan-Meier method. The log rank test was performed to assess significance in survival. Results: A total of 113 patients who underwent laparoscopic RFA for CRLM were identified. Twelve patients who underwent concurrent hepatic resection were excluded. Of the remaining patients, 64 were determined to have disease that was be technically resectable and 37 unresectable as a result of tumor number and/or distribution. Median and 5-year survival of the potentially resectable group was 4.3years and 48.7%, compared to 2.2years and 18.4% in the unresectable group (P=0.002). Median disease-free survival in the resectable group was 15.0months, compared to 16.4months in the unresectable group (P=0.796). No postoperative mortality was reported in the technically resectable group, and the rate of major complications was 3.1%. Conclusions: Laparoscopic RFA of resectable CRLM can produce comparable long-term survival to hepatic resection in carefully selected patients, with favorable morbidity and mortality. Society of Surgical Oncology, 2011 Hammill Chet Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut Billingsley Kevin Department of Surgery, Oregon Health and Science University, Portland, OR, USA aut Cassera Maria Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut Wolf Ronald Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut Ujiki Michael Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut Hansen Paul Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1947-1954 1068-9265 18:7<1947 2011 18 10434 https://doi.org/10.1245/s10434-010-1535-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1535-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hammill Chet Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut NATIONALLICENCE 700 1- Billingsley Kevin Department of Surgery, Oregon Health and Science University, Portland, OR, USA aut NATIONALLICENCE 700 1- Cassera Maria Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut NATIONALLICENCE 700 1- Wolf Ronald Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut NATIONALLICENCE 700 1- Ujiki Michael Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut NATIONALLICENCE 700 1- Hansen Paul Liver and Pancreas Surgery Program, Providence Portland Medical Center, Portland, OR, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1947-1954 1068-9265 18:7<1947 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer