caa a22 4500 445334290 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-011-1575-9 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1575-9 Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer [Elektronische Daten] [Shung-Haur Yang, Chi-Jung Huang, Shih-Ching Chang, Jen-Kou Lin] Background: An elevated plasma level of C-reactive protein (CRP) is a risk for, and prognostic factor of, colorectal cancer (CRC). In other reports of CRP concerning cardiovascular disease, CRP level correlated with its gene polymorphisms. We hypothesized that CRP polymorphisms associate risk and prognosis of CRC. Methods: This study enrolled 421 patients with CRC and 218 healthy control subjects. After preliminary studies, we selected four single nucleotide polymorphisms (SNPs) in the CRP gene: +2147A>G (rs1205), +942G>C (rs1800947), −717A>G (rs2794521), and −757T>C (rs3093059). At first, analyzing distributions of four SNPs between CRC case and non-CRC control groups was performed. Subsequently, the impacts of these SNPs with other prognostic factors of disease-free interval (DFI) and cancer-specific survival (CSS) were analyzed using uni- and multivariate Cox regression analyses. Results: The case and control groups differed in the frequency of −757T>C (P=0.002). The CRC case group had a higher percentage of the TT genotype (odds, 1.75). Regarding prognoses, multivariate analyses revealed that four factors, including stage (I, II, III), gross tumor type (polypoid, ulcerative, infiltrative), location (right, left, rectum), and −757T>C SNP (odds, 1.29; P=0.048), correlated with DFI; two factors, including stage and +2147A>G SNP (odds, 0.71; P=0.03), correlated with CSS. Conclusions: The −757T>C SNP is a risk for and prognostic factor of DFI; the +2147A>G SNP is a prognostic factor of CSS. CRP polymorphisms associate the risk and survival of CRC. Society of Surgical Oncology, 2011 Yang Shung-Haur Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan aut Huang Chi-Jung Molecular Genetics and Biochemistry Laboratory, Cathay Medical Research Institute, Cathay General Hospital, Taipei, Taiwan aut Chang Shih-Ching Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan aut Lin Jen-Kou Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1907-1915 1068-9265 18:7<1907 2011 18 10434 https://doi.org/10.1245/s10434-011-1575-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1575-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Shung-Haur Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Huang Chi-Jung Molecular Genetics and Biochemistry Laboratory, Cathay Medical Research Institute, Cathay General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chang Shih-Ching Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin Jen-Kou Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1907-1915 1068-9265 18:7<1907 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer