caa a22 4500 445334312 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-011-1564-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1564-z Liver Resection and Ablation for Metastatic Adrenocortical Carcinoma [Elektronische Daten] [R. Ripley, Clinton Kemp, Jeremy Davis, Russell Langan, Richard Royal, Steven Libutti, Seth Steinberg, Bradford Wood, Udai Kammula, Tito Fojo, Itzhak Avital] Background: Adrenocortical carcinoma (ACC) is a rare disease without effective chemotherapy treated most appropriately with resection. The aim of this study was to evaluate our experience with liver resection for metastatic ACC. Methods: This study is a retrospective review of patients who underwent liver resection or radiofrequency ablation (RFA) for ACC from 1979 to 2009. Results: A total of 27 patients were identified. Of the 27, 19 underwent liver resection. Of the 19, 10 had a single liver lesion, and 18 of 19 were rendered free of disease in the liver, although only 11 of 19 were rendered completely free of disease because of extrahepatic disease (EHD). Of the 19, 13 had synchronous EHD. Also, 6 of 17 remained disease free in the liver at a median follow-up of 6.2years (status of 2 of 19 was unknown). Of the 27 patients, 8 underwent RFA, 7 of 8 became free of disease in the liver, and 5 of 7 had EHD. No patients responded to prior chemotherapy. Median overall survival and survival of patients who underwent liver resection or RFA were both 1.9years (0.2-12+years); 5-year actuarial survivals were 29% and 29%, respectively. Disease-free interval (DFI) greater than 9months from primary resection was associated with longer survival (median 4.1 vs 0.9years; P=.013). Conclusions: This study is a tertiary institution series of liver resection and RFA for ACC. Given the lack of effective systemic treatment options and the safety of resection and ablation, liver resection or RFA may be considered in selected patients with ACC metastatic to the liver especially with a long DFI. Society of Surgical Oncology, 2011 Ripley R. Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Kemp Clinton Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Davis Jeremy Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Langan Russell Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Royal Richard Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Libutti Steven Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Steinberg Seth Biostatistics and Data Management Section, Office of the Clinical Director, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Wood Bradford Department of Diagnostic Radiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Kammula Udai Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Fojo Tito Medicine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Avital Itzhak Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1972-1979 1068-9265 18:7<1972 2011 18 10434 https://doi.org/10.1245/s10434-011-1564-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1564-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ripley R. Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Kemp Clinton Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Davis Jeremy Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Langan Russell Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Royal Richard Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Libutti Steven Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Steinberg Seth Biostatistics and Data Management Section, Office of the Clinical Director, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Wood Bradford Department of Diagnostic Radiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Kammula Udai Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Fojo Tito Medicine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Avital Itzhak Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1972-1979 1068-9265 18:7<1972 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer