caa a22 4500 445334363 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-011-1553-2 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1553-2 Interleukin-2 −330T>G Genetic Polymorphism Associates with Prognosis Following Surgery for Thoracic Esophageal Squamous Cell Cancer [Elektronische Daten] [Satoru Motoyama, Masatomo Miura, Yudai Hinai, Kiyotomi Maruyama, Shuetsu Usami, Kei Yoshino, Toshinobu Nakatsu, Hajime Saito, Yoshihiro Minamiya, Jun-ichi Ogawa] Background: Key molecules in the T helper (Th)1 and Th2 pathways underlie differential responses to the progression and surgical treatment of cancer. We investigated the relationship between Th1/Th2 cytokine polymorphism and prognosis in patients with thoracic esophageal squamous cell cancer. Materials and Methods: The study participants were 159 Japanese patients treated for thoracic esophageal squamous cell cancer with curative esophagectomy at Akita University Hospital. We determined the associations between prognosis following esophagectomy and genetic polymorphisms in Th1 cytokines (interleukin [IL]-2, Interferon-γ, IL-12β), and Th2 cytokines (IL-4, IL-10). Results: IL-2 −330T>G genetic polymorphism was significantly associated with prognosis after esophagectomy. Univariate and multivariate analyses using a Cox proportional hazards model revealed that patients carrying the IL-2 −330G/G genotype had a significantly poorer prognosis than those carrying the T/G or T/T genotype. However, IL-2 −330T>G polymorphism was not associated with preoperative serum IL-2 levels. Moreover, interferon-γ, IL-12β, IL-4, and IL-10 genetic polymorphisms were not associated with prognosis after esophagectomy for thoracic esophageal squamous cell cancer. Conclusions: It is suggested that IL-2 −330T>G genetic polymorphism may be a predictive factor for prognosis in patients receiving esophagectomy for thoracic esophageal squamous cell cancer. Society of Surgical Oncology, 2011 Motoyama Satoru Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Miura Masatomo Department of Pharmacy, Akita University Hospital, Akita, Japan aut Hinai Yudai Department of Pharmacy, Akita University Hospital, Akita, Japan aut Maruyama Kiyotomi Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Usami Shuetsu Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Yoshino Kei Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Nakatsu Toshinobu Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Saito Hajime Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Minamiya Yoshihiro Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Ogawa Jun-ichi Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1995-2002 1068-9265 18:7<1995 2011 18 10434 https://doi.org/10.1245/s10434-011-1553-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1553-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Motoyama Satoru Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Miura Masatomo Department of Pharmacy, Akita University Hospital, Akita, Japan aut NATIONALLICENCE 700 1- Hinai Yudai Department of Pharmacy, Akita University Hospital, Akita, Japan aut NATIONALLICENCE 700 1- Maruyama Kiyotomi Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Usami Shuetsu Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Yoshino Kei Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Nakatsu Toshinobu Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Saito Hajime Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Minamiya Yoshihiro Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Ogawa Jun-ichi Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 1995-2002 1068-9265 18:7<1995 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer