caa a22 4500 445334398 CHVBK 20180317142748.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1245/s10434-010-1499-9 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1499-9 Feasibility of ICG Fluorescence-Guided Sentinel Node Biopsy in animal Models using the HyperEye Medical System [Elektronische Daten] [Kohichi Yamauchi, Hiroshi Nagafuji, Takehiro Nakamura, Takayuki Sato, Naoyuki Kohno] Background: The sentinel lymph node (SLN) concept is accepted for several types of cancers. Current methods for sentinel node detection involve radioisotopes and blue dye. They have shown good results, but some drawbacks remain. Indocyanine green (ICG) fluorescence using the HyperEye Medical System (HEMS) was evaluated as a new method. Methods: This was a prospective, nonrandomized, experimental study in four Japanese white rabbits and six Yorkshire pigs. ICG and indigo carmine were injected into the tongue, larynx, or hypopharynx, and ICG fluorescence detection was evaluated using both transcutaneous visualization of lymphatic vessels and intraoperative identification of SLNs. Results: The SLNs appeared as shining fluorescent spots with HEMS transcutaneously in rabbits, but no SLNs were detected transcutaneously in pigs. Eleven procedures identified SLNs, but one did not due to a technical problem. Conclusions: HEMS could become useful for predicting lymph node metastasis during surgery for head and neck cancer. Society of Surgical Oncology, 2011 Yamauchi Kohichi Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut Nagafuji Hiroshi Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut Nakamura Takehiro Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut Sato Takayuki Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan aut Kohno Naoyuki Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2042-2047 1068-9265 18:7<2042 2011 18 10434 https://doi.org/10.1245/s10434-010-1499-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1499-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamauchi Kohichi Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagafuji Hiroshi Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Takehiro Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut NATIONALLICENCE 700 1- Sato Takayuki Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan aut NATIONALLICENCE 700 1- Kohno Naoyuki Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/7(2011-07-01), 2042-2047 1068-9265 18:7<2042 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer