caa a22 4500 445334487 CHVBK 20180317142749.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1752-x doi (NATIONALLICENCE)springer-10.1245/s10434-011-1752-x Prognostic Significance of Stromal Microinvasion in the Intestinal Type of Ovarian Mucinous Adenocarcinoma [Elektronische Daten] [Kun-Young Kong, Jeong-Yeol Park, Dae-Yeon Kim, Jong-Hyeok Kim, Yong-Man Kim, Kyu-Rae Kim, Young-Tak Kim, Joo-Hyun Nam] Background: The purpose of this study was to assess clinical outcomes with respect to the extent of stromal invasion in patients with stage I ovarian mucinous adenocarcinoma (MAC) of the intestinal type. Methods: We retrospectively reviewed the medical records and pathologic slides of 113 patients with stage I ovarian MACs who were treated at the Asan Medical Center from January 1994 to July 2009. According to the recent histopathologic criteria, MACs were classified into 3 groups: intraepithelial carcinoma without invasion (IEC), intraepithelial carcinoma with microinvasion (IECMI), and mucinous adenocarcinoma with extensive invasion (MACEI). Stromal invasion was confined to the tumors showing severe cytologic atypia in the invasive foci. Therefore, cases showing mucin granulomas composed only of macrophages without malignant cells were excluded from the definition of invasion. Results: Of the 113 patients, 54 (47.8%) had IEC, 15 (13.3%) had IECMI, and 44 (38.9%) had MACEI. There were no differences among groups in age, menopausal status, CA-125 level, surgical procedures, stage, capsular and lymphovascular space invasion. The 5-year disease-free-survival rates in the IEC, IECMI, and MACEI groups were 97.7%, 77.3%, and 79.9%, respectively (IEC vs IECMI, P=0.004; IEC vs MACEI, P=0.012; IECMI vs MACEI, P=0.555). Prognosis was significantly poorer for patients with IECMI than for those with IEC, but not different between patients with IECMI and MACEI. Conclusions: Stromal microinvasion in ovarian MAC is a significant prognostic factor. Therefore, diligent search for "stromal microinvasion” with adequate sampling of tumor tissue are important at the time of histopathologic diagnosis, and patients with IECMI should no longer be treated identically to those with IEC. Society of Surgical Oncology, 2011 Kong Kun-Young Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Park Jeong-Yeol Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Kim Dae-Yeon Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Kim Jong-Hyeok Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Kim Yong-Man Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Kim Kyu-Rae Department of Pathology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Kim Young-Tak Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Nam Joo-Hyun Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3462-3468 1068-9265 18:12<3462 2011 18 10434 https://doi.org/10.1245/s10434-011-1752-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1752-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kong Kun-Young Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Park Jeong-Yeol Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Dae-Yeon Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jong-Hyeok Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Yong-Man Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyu-Rae Department of Pathology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Young-Tak Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Nam Joo-Hyun Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3462-3468 1068-9265 18:12<3462 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer