caa a22 4500 445334517 CHVBK 20180317142749.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1763-7 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1763-7 Clinical Implications of Bilateral Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Cancer: A Risk Factor for Lung Metastasis [Elektronische Daten] [Yoon Lee, Yun Lim, Jin-Choon Lee, Soo-Geun Wang, In-Ju Kim, Seok-Man Son, Byung-Joo Lee] Background: Distant metastasis to the lung in papillary thyroid cancer (PTC) is rarely detected, but it is known to be an important prognostic factor associated with survival. We investigated risk factors for lung metastasis in PTC. Materials and Methods: We performed a retrospective review of patients with PTC (n=977) who were treated from January 2006 to August 2009. Enrolled patients received radioablation therapy followed by a radioiodine whole body scan. Lung metastasis was screened out with whole body scan or positron emission tomography/computed tomography (PET/CT) and confirmed with chest CT. Age, gender, extrathyroidal extension, central lymph node metastasis, lateral lymph node metastasis, and bilateral lateral cervical lymph node metastasis (BLNM) were investigated to analyze the relationship with lung metastasis. Results: In total, 949 patients were enrolled. The median age was 49years (±13years) with 829 women. Lung metastasis was found in 20 patients (2.1%). Patients were divided into three groups by tumor size (≤1cm, 1-2cm, >2cm); the groups comprised 47.3%, 28.5%, and 24.1% of the patients, respectively. BLNM was identified in 4.4% (n=43). In a univariate analysis, male gender, old age, large tumor, extrathyroidal extension, lymph node metastasis, lateral lymph node metastasis, and BLNM were significantly related to lung metastasis (P<0.05). In a multivariate analysis, BLNM appeared to be the only significant risk factor for lung metastasis (P=0.026; odds ratio=10.219). Conclusions: BLNM may be a risk factor for lung metastasis. This indicates that careful examinations, including chest CT and positron emission tomography (PET), are recommended during the follow-up period when BLNM is suspected. Society of Surgical Oncology, 2011 Lee Yoon Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut Lim Yun Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut Lee Jin-Choon Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut Wang Soo-Geun Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut Kim In-Ju Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut Son Seok-Man Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Kyungnam, Republic of Korea aut Lee Byung-Joo Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3486-3492 1068-9265 18:12<3486 2011 18 10434 https://doi.org/10.1245/s10434-011-1763-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1763-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Yoon Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut NATIONALLICENCE 700 1- Lim Yun Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut NATIONALLICENCE 700 1- Lee Jin-Choon Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut NATIONALLICENCE 700 1- Wang Soo-Geun Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut NATIONALLICENCE 700 1- Kim In-Ju Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut NATIONALLICENCE 700 1- Son Seok-Man Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Kyungnam, Republic of Korea aut NATIONALLICENCE 700 1- Lee Byung-Joo Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3486-3492 1068-9265 18:12<3486 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer