caa a22 4500 445334533 CHVBK 20180317142749.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1697-0 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1697-0 Selective Organ Preservation in Operable Locally Advanced Head and Neck Squamous Cell Carcinomas Guided by Primary Site Restaging Biopsy: Long-Term Results of Two Sequential Brown University Oncology Group Chemoradiotherapy Studies [Elektronische Daten] [Harold Wanebo, Ritesh Rathore, Prakash Chougule, Michael DiSiena, R. Koness, Robert McRae, Peter Nigri, Kathy Radie-Keane, Neal Ready] Objectives: The long-term outcomes of selective organ preservation in operable, locally advanced head and neck cancers in two sequential chemoradiotherapy (CRT) protocols (HN-53, HN-67) are reported. Methods: A total of 65 patients were treated with CRT consisting of carboplatin (AUC=1/week) and paclitaxel (60 or 40mg/m2/week) with radiation (1.8Gy/day). After 5weeks of CRT, if primary site biopsies were pathologically negative, then completion CRT to 67-72Gy was done with neck dissection in node-positive cases. Alternatively, a positive rebiopsy required primary site resection and neck dissection followed by radiotherapy boost as deemed necessary. Results: Pathologic complete responses occurred in 71% patients who then completed CRT; the remaining 29% patients underwent primary site surgery. The 5-year and median overall survival were 47% and 57months with no statistically significant differences between the two groups. Overall long-term failure rates were: 6% local, 6% regional, and 32% distant. Conclusions: This strategy of selective organ preservation was effective in 71% patients with CRT, whereas salvage surgery was required in the remainder. Long-term survival was equivalent in both treatment groups. Society of Surgical Oncology, 2011 Wanebo Harold Division of Surgical Oncology, Landmark Medical Center, Woonsocket, RI, USA aut Rathore Ritesh Division of Hematology/Oncology, Roger Williams Medical Center, Providence, RI, USA aut Chougule Prakash Maddock Center for Radiation Oncology, Warwick, RI, USA aut DiSiena Michael Division of Surgical Oncology, Roger Williams Hospital, Providence, RI, USA aut Koness R. Division of Surgical Oncology, Roger Williams Hospital, Providence, RI, USA aut McRae Robert Department of Otolaryngology, Rhode Island Hospital, Providence, RI, USA aut Nigri Peter Department of Otolaryngology, Rhode Island Hospital, Providence, RI, USA aut Radie-Keane Kathy North Main Radiation Oncology, Providence, RI, USA aut Ready Neal Division of Hematology/Oncology, Duke Medical Center, Durham, NC, USA aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3479-3485 1068-9265 18:12<3479 2011 18 10434 https://doi.org/10.1245/s10434-011-1697-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1697-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wanebo Harold Division of Surgical Oncology, Landmark Medical Center, Woonsocket, RI, USA aut NATIONALLICENCE 700 1- Rathore Ritesh Division of Hematology/Oncology, Roger Williams Medical Center, Providence, RI, USA aut NATIONALLICENCE 700 1- Chougule Prakash Maddock Center for Radiation Oncology, Warwick, RI, USA aut NATIONALLICENCE 700 1- DiSiena Michael Division of Surgical Oncology, Roger Williams Hospital, Providence, RI, USA aut NATIONALLICENCE 700 1- Koness R. Division of Surgical Oncology, Roger Williams Hospital, Providence, RI, USA aut NATIONALLICENCE 700 1- McRae Robert Department of Otolaryngology, Rhode Island Hospital, Providence, RI, USA aut NATIONALLICENCE 700 1- Nigri Peter Department of Otolaryngology, Rhode Island Hospital, Providence, RI, USA aut NATIONALLICENCE 700 1- Radie-Keane Kathy North Main Radiation Oncology, Providence, RI, USA aut NATIONALLICENCE 700 1- Ready Neal Division of Hematology/Oncology, Duke Medical Center, Durham, NC, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3479-3485 1068-9265 18:12<3479 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer