caa a22 4500 445334584 CHVBK 20180317142750.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1732-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1732-1 FDG-PET Parameters as Prognostic Factor in Esophageal Cancer Patients: A Review [Elektronische Daten] [J. Omloo, M. van Heijl, O. Hoekstra, M. van Berge Henegouwen, J. van Lanschot, G. Sloof] Background: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been used extensively to explore whether FDG Uptake can be used to provide prognostic information for esophageal cancer patients. The aim of the present review is to evaluate the literature available to date concerning the potential prognostic value of FDG uptake in esophageal cancer patients, in terms of absolute pretreatment values and of decrease in FDG uptake during or after neoadjuvant therapy. Methods: A computer-aided search of the English language literature concerning esophageal cancer and standardized uptake values was performed. This search focused on clinical studies evaluating the prognostic value of FDG uptake as an absolute value or the decrease in FDG uptake and using overall mortality and/or disease-related mortality as an end point. Results: In total, 31 studies met the predefined criteria. Two main groups were identified based on the tested prognostic parameter: (1) FDG uptake and (2) decrease in FDG uptake. Most studies showed that pretreatment FDG uptake and postneoadjuvant treatment FDG uptake, as absolute values, are predictors for survival in univariate analysis. Moreover, early decrease in FDG uptake during neoadjuvant therapy is predictive for response and survival in most studies described. However, late decrease in FDG uptake after completion of neoadjuvant therapy was predictive for pathological response and survival in only 2 of 6 studies. Conclusions: Measuring decrease in FDG uptake early during neoadjuvant therapy is most appealing, moreover because the observed range of values expressed as relative decrease to discriminate responding from nonresponding patients is very small. At present inter-institutional comparison of results is difficult because several different normalization factors for FDG uptake are in use. Therefore, more research focusing on standardization of protocols and inter-institutional differences should be performed, before a PET-guided algorithm can be universally advocated. The Author(s), 2011 Omloo J. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut van Heijl M. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut Hoekstra O. The Department of Nuclear Medicine and PET Research, VU Medical Center, Amsterdam, The Netherlands aut van Berge Henegouwen M. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut van Lanschot J. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut Sloof G. Department of Nuclear Medicine, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3338-3352 1068-9265 18:12<3338 2011 18 10434 https://doi.org/10.1245/s10434-011-1732-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1732-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Omloo J. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Heijl M. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Hoekstra O. The Department of Nuclear Medicine and PET Research, VU Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Berge Henegouwen M. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Lanschot J. Department of Surgery, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Sloof G. Department of Nuclear Medicine, The Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3338-3352 1068-9265 18:12<3338 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer