caa a22 4500 445334665 CHVBK 20180317142750.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1734-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1734-z Axillary Failure in Patients Treated with MammoSite Accelerated Partial Breast Irradiation [Elektronische Daten] [Majd Aburabia, Robert Roses, Henry Kuerer, Richard Fine, Peter Beitsch, Sharad Goyal, Bruce Haffty, Maureen Lyden, Frank Vicini] Background: The risk of axillary failure (AF) after accelerated partial breast irradiation (APBI) using MammoSite brachytherapy is unknown and has been source of concern as the axillary region is not treated with this technique. We aimed to determine the rate of AF in patients treated with APBI and identify factors associated with its occurrence. Methods: Data from the American Society of Breast Surgeons MammoSite Registry Trial were reviewed and patients with AF were identified. Clinical, pathologic and treatment-related variables were analyzed to determine which factors were associated with AF. Results: A total of 1440 patients underwent MammoSite APBI. A total of 1449 cases were treated (9 patients received bilateral treatment), 1255 cases (87%) of invasive breast cancer and 194 cases (13%) of ductal carcinoma in situ (DCIS). The median length of follow-up was 59months. There were 10 patients who had an AF. Of these, 9 patients had an initial diagnosis of invasive cancer and 1 had an initial diagnosis of DCIS. The 5-year actuarial rate of AF was 0.79%. The only independent risk factor for AF identified by multivariate analysis was the presence of high-grade disease (P=.008). The 5-year overall survival rate in patients with an AF was 77.8% (there was 1 death related to breast cancer). Conclusions: The rate of AF after MammoSite APBI is low and appears to be similar to that achieved with whole-breast irradiation. Society of Surgical Oncology, 2011 Aburabia Majd Department of Surgery, William Beaumont Hospital, Royal Oak, MI, USA aut Roses Robert Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Kuerer Henry Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Fine Richard Advanced Breast Care of Georgia, Marietta, GA, USA aut Beitsch Peter Department of Surgery, Dallas Breast Center, Dallas, TX, USA aut Goyal Sharad Department of Radiation Oncology, The Cancer Institute of New Jersey and UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USA aut Haffty Bruce Department of Radiation Oncology, The Cancer Institute of New Jersey and UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USA aut Lyden Maureen BioStat International, Tampa, FL, USA aut Vicini Frank Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3415-3421 1068-9265 18:12<3415 2011 18 10434 https://doi.org/10.1245/s10434-011-1734-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1734-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aburabia Majd Department of Surgery, William Beaumont Hospital, Royal Oak, MI, USA aut NATIONALLICENCE 700 1- Roses Robert Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Kuerer Henry Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Fine Richard Advanced Breast Care of Georgia, Marietta, GA, USA aut NATIONALLICENCE 700 1- Beitsch Peter Department of Surgery, Dallas Breast Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Goyal Sharad Department of Radiation Oncology, The Cancer Institute of New Jersey and UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USA aut NATIONALLICENCE 700 1- Haffty Bruce Department of Radiation Oncology, The Cancer Institute of New Jersey and UMDNJ/Robert Wood Johnson Medical School, New Brunswick, NJ, USA aut NATIONALLICENCE 700 1- Lyden Maureen BioStat International, Tampa, FL, USA aut NATIONALLICENCE 700 1- Vicini Frank Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3415-3421 1068-9265 18:12<3415 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer