caa a22 4500 445334673 CHVBK 20180317142750.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1740-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1740-1 Clinical Significance of Pre- to Post-Chemoradiotherapy s-CEA Reduction Ratio in Rectal Cancer Patients Treated with Preoperative Chemoradiotherapy and Curative Resection [Elektronische Daten] [Chan Kim, Chang Yu, Song-Soo Yang, Kyung Kim, Yong Yoon, Sang Yoon, Seok-Byung Lim, Jin Kim] Purpose: To evaluate the clinical significance of a reduction in serum carcinoembryonic antigen (s-CEA) concentration ratio from before to after preoperative chemoradiotherapy (CRT) in terms of recurrence and prognostic factors in rectal cancer patients. Methods: We retrospectively evaluated 333 rectal cancer patients who received preoperative CRT followed by surgery with curative intent between January 2000 and December 2006. Patients were divided into three groups: those with pre-CRT s-CEA≤6ng/mL (group 1), those with pre-CRT s-CEA>6mg/mL and post-CRT s-CEA≥70% lower than pre-CRT s-CEA (group 2), and those with pre-CRT s-CEA>6mg/mL and post-CRT s-CEA<70% lower or higher than pre-CRT s-CEA (group 3). Results: The 5-year disease-free survival rate was similar in group 1 (76.0%) and group 2 (66.0%), but significantly lower in group 3 (39.5%) (p<0.001). Multivariate analysis showed that CEA group 3, ypT stage, ypN stage, and type of surgery were independent prognostic factors for disease-free survival. Conclusions: The reduction ratio of pre- to post-CRT s-CEA concentration may be an independent prognostic factor for disease-free survival following preoperative CRT and surgery in rectal cancer patients with initial s-CEA>6ng/mL. Society of Surgical Oncology, 2011 Kim Chan Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Yu Chang Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Yang Song-Soo Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Kim Kyung Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Yoon Yong Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Yoon Sang Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Lim Seok-Byung Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Kim Jin Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3271-3277 1068-9265 18:12<3271 2011 18 10434 https://doi.org/10.1245/s10434-011-1740-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1740-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Chan Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Yu Chang Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Yang Song-Soo Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyung Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Yoon Yong Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Yoon Sang Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Lim Seok-Byung Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jin Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Songpa-Ku, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3271-3277 1068-9265 18:12<3271 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer