caa a22 4500 445334754 CHVBK 20180317142750.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1747-7 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1747-7 Survival Factors in Patients with Recurrence After Curative Resection of Esophageal Squamous Cell Carcinomas [Elektronische Daten] [Hiroshi Miyata, Makoto Yamasaki, Yukinori Kurokawa, Shuji Takiguchi, Kiyokazu Nakajima, Yoshiyuki Fujiwara, Koji Konishi, Masaki Mori, Yuichiro Doki] Background: Approximately half of patients who undergo curative resection for esophageal cancers develop recurrence postoperatively. The factors affecting survival after such recurrence remain largely unknown. Methods: To investigate factors affecting survival after recurrence in patients who had undergone curative resection for esophageal cancer, we retrospectively reviewed data for 461 patients who underwent curative esophagectomy with or without preoperative therapy for esophageal squamous cell carcinoma from January 1996 to December 2007. The correlations between several clinicopathological factors and survival after recurrence were examined. Results: Recurrence occurred in 196 of 461 patients (42.5%), with a median survival time after recurrence of 8.2months. Multivariate analysis identified advanced tumor stage, preoperative chemoradiotherapy (CRT), number of recurrent tumors, and the presence of recurrence at the local site and liver as associated with shortened survival after recurrence. The analysis also indicated that treatment of the recurrence prolonged survival regardless of the treatment type. Although the pattern of recurrence did not significantly differ according to type of preoperative therapy, patients who underwent preoperative CRT were less often treated with radiotherapy for recurrence. Patients with multiple recurrent tumors less often received radiotherapy or surgery than those with a solitary recurrence. Chemotherapy for recurrence was not associated with either preoperative therapy or the number of recurrences. Conclusions: Our retrospective study showed that multiple recurrent tumors and preoperative CRT limit the available treatment for recurrence and thereby are associated with poor prognosis. Vigorous treatment for recurrence can extend survival after recurrence in patients who undergo esophagectomy. Society of Surgical Oncology, 2011 Miyata Hiroshi Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Yamasaki Makoto Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Kurokawa Yukinori Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Takiguchi Shuji Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Nakajima Kiyokazu Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Fujiwara Yoshiyuki Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Konishi Koji Radiation Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan aut Mori Masaki Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Doki Yuichiro Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3353-3361 1068-9265 18:12<3353 2011 18 10434 https://doi.org/10.1245/s10434-011-1747-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1747-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyata Hiroshi Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Yamasaki Makoto Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Kurokawa Yukinori Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Takiguchi Shuji Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Nakajima Kiyokazu Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Fujiwara Yoshiyuki Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Konishi Koji Radiation Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Mori Masaki Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Doki Yuichiro Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3353-3361 1068-9265 18:12<3353 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer