caa a22 4500 445334762 CHVBK 20180317142751.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1725-0 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1725-0 High Expression of Y-Box-Binding Protein-1 is Associated with Poor Survival in Resectable Esophageal Squamous Cell Carcinoma [Elektronische Daten] [Yong Li, Zhe-Sheng Wen, Hao-Xian Yang, Rong-Zhen Luo, Ying Zhang, Mei-Fang Zhang, Xin Wang, Wei-Hua Jia] Background: Y-box-binding protein-1 (YB-1) is a multifunctional protein that regulates gene expression through both transcriptional and translational mechanism. Its expression has been associated with tumor progression and poor prognosis of many cancers. However, its role and clinical significance in resectable esophageal squamous cell carcinoma (ESCC) is still scanty. The purpose of this study was to investigate the prognostic significance of YB-1 expression by immunohistochemistry in a group of patients with ESCC treated with surgical resection. Methods: Tissue microarray that included 233 surgically resected ESCC specimens and 49 cases of adjacent normal tissues was successfully generated for immunohistochemical evaluation. The clinical/prognostic significance of YB-1 expression was statistically analyzed. Kaplan-Meier analysis was used to compare the postoperative survival between groups. Results: The results showed the immunostaining of YB-1 was distributed predominantly in cytoplasm in tumor cells, which occurred in all of the 233 patients. A higher recurrence (disease-free survival) and lower survival (overall survival) of ESCC was found in patients whose tissues had increased YB-1 expression (P<.001/P=.001). Furthermore, YB-1 expression could stratify the patient survival (disease-free survival/overall survival) in stage II (P=.012/.016). The Cox proportionate hazard regression model also established that high YB-1 expression was significantly correlated with increased risk (RR=1.752) of recurrence compared with lowYB-1 expression (P=.004). Conclusions: High expression of YB-1 is associated with poor survival in resectable ESCC patients. Society of Surgical Oncology, 2011 Li Yong Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut Wen Zhe-Sheng Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut Yang Hao-Xian Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut Luo Rong-Zhen Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut Zhang Ying State Key Laboratory of Oncology in South China, Guangzhou City, Guangdong Province, People's Republic of China aut Zhang Mei-Fang Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut Wang Xin Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut Jia Wei-Hua State Key Laboratory of Oncology in South China, Guangzhou City, Guangdong Province, People's Republic of China aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3370-3376 1068-9265 18:12<3370 2011 18 10434 https://doi.org/10.1245/s10434-011-1725-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1725-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Yong Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Wen Zhe-Sheng Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Yang Hao-Xian Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Luo Rong-Zhen Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Ying State Key Laboratory of Oncology in South China, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Mei-Fang Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Wang Xin Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 700 1- Jia Wei-Hua State Key Laboratory of Oncology in South China, Guangzhou City, Guangdong Province, People's Republic of China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3370-3376 1068-9265 18:12<3370 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer