caa a22 4500 445334797 CHVBK 20180317142751.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1245/s10434-011-1663-x doi (NATIONALLICENCE)springer-10.1245/s10434-011-1663-x Incidental Papillary Microcarcinoma of the Thyroid—Further Evidence of a Very Low Malignant Potential: A Retrospective Clinicopathological Study With Up to 30Years of Follow-Up [Elektronische Daten] [Nikolaus Neuhold, Andrea Schultheis, Michael Hermann, Gabriela Krotla, Oskar Koperek, Peter Birner] Background: Despite the frequent occurrence of papillary microcarcinoma (PMC) of the thyroid, no consensus on its malignant potential or its treatment exists. The objective of this study was to analyze the clinicopathological characteristics of a retrospective cohort of consecutive patients with PMC treated in a single institution during a 30-year period and to study the incidence rates of PMC in all patients operated on for thyroid diseases during this period. Methods: Demographic data, clinical characteristics, histological workup of the resected glands, histopathological features, treatment, and follow-up data were studied. Results: Between 1975 and 1994, 759 PMCs were detected in 28,197 patients who received thyroidal surgery. The detection rate of PMC was significantly determined by the accuracy of the histological examination. Only 5 patients with PMC presented with clinically apparent lymph node metastases and 754 were incidental PMCs. Mean follow-up was 88±2 (range, 11-639) months. Only three patients experienced recurrence in cervical lymph nodes, all of whom presented with clinically suspect cervical nodes. No patient died of disease. Clinically apparent lymph node metastases and stage pT3 were significantly associated with recurrence. Conclusions: Incidentally detected PMC, even when multifocal, is a biologically indolent tumor that seldom if ever progresses. In contrast, clinically occult PMC detected due to clinically suspected and histological confirmed lymph node metastases or extrathyroidal growth may show a more aggressive course with disease recurrence and an eventual poorer prognosis. Society of Surgical Oncology, 2011 Neuhold Nikolaus Department of Pathology and Bacteriology, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut Schultheis Andrea Department of Pathology and Bacteriology, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut Hermann Michael Department of Surgery, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut Krotla Gabriela Department of Nuclear Medicine, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut Koperek Oskar Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria aut Birner Peter Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria aut Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3430-3436 1068-9265 18:12<3430 2011 18 10434 https://doi.org/10.1245/s10434-011-1663-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1663-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Neuhold Nikolaus Department of Pathology and Bacteriology, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut NATIONALLICENCE 700 1- Schultheis Andrea Department of Pathology and Bacteriology, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut NATIONALLICENCE 700 1- Hermann Michael Department of Surgery, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut NATIONALLICENCE 700 1- Krotla Gabriela Department of Nuclear Medicine, Kaiserin-Elisabeth-Spital der Stadt Wien, Vienna, Austria aut NATIONALLICENCE 700 1- Koperek Oskar Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Birner Peter Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/12(2011-11-01), 3430-3436 1068-9265 18:12<3430 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer