caa a22 4500 445334827 CHVBK 20180317142751.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1377-5 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1377-5 The Value of Postoperative Parathyroid Hormone Levels in Predicting the Need for Long-Term Vitamin D Supplementation after Total Thyroidectomy [Elektronische Daten] [Tracy Wang, Ashley Cayo, Stuart Wilson, Tina Yen] Background: Few studies have examined the need for vitamin D supplementation after total thyroidectomy. This study examines the role of postoperative day (POD) 1 serum calcium and parathyroid hormone (PTH) levels in predicting the need for long-term vitamin D supplementation after total thyroidectomy. Methods: A retrospective, single institutional study of patients who underwent total thyroidectomy between January 2007 and December 2008 was performed. Data collected included extent of surgery, final pathology, postoperative calcium (mg/dl) and PTH (pg/ml) values, and duration of vitamin D supplementation. Patients were divided into 4 groups based on POD1 PTH values: group 1 (<5.0); group 2 (5.0-10); group 3 (10.1-20); and group 4 (>20). Results: Of the 104 patients, 26 were in group 1, 12 in group 2, 18 in group 3, and 48 in group 4, with median PTH values of <2.5, 8.2, 14.1, and 30pg/ml, respectively. All 7 (7%) patients who required vitamin D supplementation >1month were in group 1. The positive predictive value of POD1 PTH <5.0 in predicting supplementation >1month was 27% (sensitivity 100%, specificity 80%). Seventy-eight patients had a POD1 PTH level ≥5, and none required vitamin D supplementation >1month (100% negative predictive value). The positive predictive value of various POD1 calcium thresholds (<7.5, <8.0, and <8.5mg/dl) was 17, 14, and 15%, respectively. Conclusions: Postoperative PTH levels better predict long-term hypocalcemia requiring vitamin D supplementation than serum calcium levels. A PTH level ≥5.0 may identify patients who can be safely discharged without routine vitamin D supplementation. Society of Surgical Oncology, 2010 Wang Tracy Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut Cayo Ashley Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut Wilson Stuart Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut Yen Tina Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 777-781 1068-9265 18:3<777 2011 18 10434 https://doi.org/10.1245/s10434-010-1377-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1377-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Tracy Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Cayo Ashley Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Wilson Stuart Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Yen Tina Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 777-781 1068-9265 18:3<777 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer