caa a22 4500 445334894 CHVBK 20180317142751.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1338-z doi (NATIONALLICENCE)springer-10.1245/s10434-010-1338-z Loss of E-cadherin and MUC2 Expressions Correlated with Poor Survival in Patients with Stages II and III Colorectal Carcinoma [Elektronische Daten] [Haeyoun Kang, Byung Min, Kang Lee, Nam Kim, Soo Kim, Junjeong Choi, Hoguen Kim] Background: With the recent development of molecular markers, it has become possible to characterize colorectal carcinomas beyond clinical and histologic aspects. When considered together with tumor stage, molecular markers will allow us further insight into individual tumor biologies and prognoses. Purpose: To investigate the expression and prognostic implications of the molecular markers, p53, bcl-2, Rb, hMLH1, hMSH2, β-catenin, E-cadherin, and MUC-2. Methods: We analyzed the clinical, histologic, and molecular factors for 229 patients with colorectal carcinoma of stage II and III and compared their prognoses. We used tissue microarrays to analyze the expressions of molecular markers and to assess their correlations with prognosis. Semiquantitative expressions of molecular markers and clinicopathologic parameters were analyzed with respect to prognosis. Results: Among the clinicopathologic parameters, left-sided location, age older than 70years, higher preoperative serum carcinoembryonic antigen (CEA) level (≤5ng/mL), irregular growth pattern, and perineural invasion were significantly related to poor prognosis in stage II and III patients. For molecular factors, loss of expression of E-cadherin and MUC-2 showed significant correlation with poor overall survival in both cancer stages. Multivariate analysis showed that higher TNM stage, higher preoperative serum CEA level (≤5ng/mL), perineural tumor cell invasion, and loss of E-cadherin and MUC-2 expressions were independently correlated with poor overall survival. Conclusions: Our results indicated that of the analyzed molecular markers, MUC-2 and E-cadherin might be useful in predicting prognosis and planning for adjuvant therapy in patients with stage II and III colorectal carcinomas. Society of Surgical Oncology, 2010 Kang Haeyoun Department of Pathology, CHA University College of Medicine, Seongnam, Korea aut Min Byung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Lee Kang Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Kim Nam Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Kim Soo Department of Obstetrics and Gynecology, Kunkook University College of Medicine, Seoul, Korea aut Choi Junjeong Department of Pathology and Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea aut Kim Hoguen Department of Pathology and Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 711-719 1068-9265 18:3<711 2011 18 10434 https://doi.org/10.1245/s10434-010-1338-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1338-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kang Haeyoun Department of Pathology, CHA University College of Medicine, Seongnam, Korea aut NATIONALLICENCE 700 1- Min Byung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Kang Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Nam Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Soo Department of Obstetrics and Gynecology, Kunkook University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Junjeong Department of Pathology and Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Hoguen Department of Pathology and Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 711-719 1068-9265 18:3<711 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer