caa a22 4500 445334924 CHVBK 20180317142751.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1387-3 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1387-3 Prognostic Significance of CD151 Expression in Esophageal Squamous Cell Carcinoma with Aggressive Cell Proliferation and Invasiveness [Elektronische Daten] [Shigemasa Suzuki, Tatsuya Miyazaki, Naritaka Tanaka, Makoto Sakai, Akihiko Sano, Takanori Inose, Makoto Sohda, Masanobu Nakajima, Hiroyuki Kato, Hiroyuki Kuwano] Background: CD151 is a member of the tetraspanins and has recently been reported as a promoter of the malignant progression of cancer. The purpose of this study was to clarify the clinicopathological outcome and prognostic significance of the immunohistochemical expression of CD151 in esophageal squamous cell carcinoma (ESCC). Methods: We evaluated the significance of CD151 expression by immunohistochemistry in 138 surgically resected ESCC and the association of CD151 expression with clinicopathological features. Results: Seventy-five (51.7%) ESCC showed a positive expression of CD151, which indicated a significant association with tumor depth (P=0.004), lymph node metastasis (P=0.002), distant metastasis (P=0.025), and lymphatic invasion (P=0.046), as well as the Ki-67 labeling index (P=0.011). The 5-year survival rate of ESCC patients with CD151-positive expression was significantly lower than with CD151-negative expression (positive, 43.1%; negative, 63.8%; P=0.003). Multivariate analysis showed that positive CD151 expression was not an independent factor for poor survival (P=0.096). Conclusions: CD151 expression is associated with tumor proliferation and invasiveness in ESCC. Society of Surgical Oncology, 2010 Suzuki Shigemasa Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Miyazaki Tatsuya Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Tanaka Naritaka Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Sakai Makoto Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Sano Akihiko Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Inose Takanori Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Sohda Makoto Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Nakajima Masanobu Department of Surgical Oncology, Dokkyo Medical University, Mibu, Tochigi, Japan aut Kato Hiroyuki Department of Surgical Oncology, Dokkyo Medical University, Mibu, Tochigi, Japan aut Kuwano Hiroyuki Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 888-893 1068-9265 18:3<888 2011 18 10434 https://doi.org/10.1245/s10434-010-1387-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1387-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Shigemasa Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Miyazaki Tatsuya Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Tanaka Naritaka Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Sakai Makoto Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Sano Akihiko Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Inose Takanori Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Sohda Makoto Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Nakajima Masanobu Department of Surgical Oncology, Dokkyo Medical University, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Kato Hiroyuki Department of Surgical Oncology, Dokkyo Medical University, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Kuwano Hiroyuki Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 888-893 1068-9265 18:3<888 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer