caa a22 4500 445334975 CHVBK 20180317142751.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1372-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1372-x Prospective Evaluation of Laparoscopic Celiac Plexus Block in Patients with Unresectable Pancreatic Adenocarcinoma [Elektronische Daten] [Peter Allen, Joanne Chou, Maria Janakos, Vivian Strong, Daniel Coit, Murray Brennan] Introduction: The efficacy of laparoscopic celiac plexus block (CPB) in patients with unresectable pancreatic cancer has not been reported. Methods: Patients with elevated pain scores scheduled for laparoscopy for diagnosis/staging of unresectable pancreatic adenocarcinoma were eligible. The study was designed to evaluate 20 consecutive patients with validated quality of life (EORTC QLQ-C30, QLQ-PAN26) and validated pain assessment tools [Brief Pain Inventory (BPI)]. Questionnaires were obtained preoperatively, and postoperatively at 1, 4, and 8weeks. Laparoscopic CPB was performed by bilateral injection of 20cc 50% alcohol utilizing a recently described laparoscopic technique. Functional and symptom scoring was performed by EORTC scoring manual. Results: Median age was 61years (range 42-80years), and mean preoperative pain score [worst in 24h on 0-10 visual analogue scale (VAS)] was 7.8 [standard deviation (SD) 1.6]. Median total operative time (laparoscopy+biopsy+CBP) was 57min (range 29-92min), and all patients except one were discharged on day of surgery. No major complications occurred. EORTC functional scales did not change significantly during the postoperative period. EORTC symptomatic pain scores decreased significantly. These findings were also observed in the BPI, with significant decreases in visual analogue score for reported mean (preoperative versus week 4, mean: 5.7 versus 2.7; p<0.01) and worst (preoperative versus week 4, mean: 7.8 versus 5.1; p<0.01) pain during a 24-h period. Conclusions: This study documents the efficacy of laparoscopic CPB. The procedure was associated with minimal morbidity, brief operative times, outpatient management, and reduction in pain scores similar to that reported with other approaches to celiac neurolysis. Society of Surgical Oncology, 2010 Allen Peter The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Chou Joanne The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Janakos Maria The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Strong Vivian The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Coit Daniel The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Brennan Murray The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 636-641 1068-9265 18:3<636 2011 18 10434 https://doi.org/10.1245/s10434-010-1372-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1372-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Allen Peter The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Chou Joanne The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Janakos Maria The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Strong Vivian The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Coit Daniel The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Brennan Murray The Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 636-641 1068-9265 18:3<636 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer