caa a22 4500 445335076 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1291-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1291-x Prognostic Impact of Inferior Mesenteric Artery Lymph Node Metastasis in Colorectal Cancer [Elektronische Daten] [Jeonghyun Kang, Hyuk Hur, Byung Min, Nam Kim, Kang Lee] Aim: The aims of this study are to identify the natural course of inferior mesenteric artery (IMA) lymph node metastasis, and to evaluate the prognostic impact of IMA lymph node metastasis in the sigmoid colon and rectal cancer. Patients and Methods: From our prospectively collected database, a total of 625 patients who underwent resection with curative intent for stage III adenocarcinoma of the sigmoid colon and rectal cancer between June 1995 and June 2007 were selected. Patients were divided into the IMA-positive group (n=33) and the IMA-negative group (n=592) according to IMA lymph node metastasis status. Clinicopathological features, recurrence patterns, and 5-year disease-free survival rates were compared between the two groups. Results: Following curative resection, 5-year disease-free survival rate was 31.9% in the IMA-positive group and 69.4% in the IMA-negative group (p<0.001). Cox regression analysis revealed that rectal cancer, pathologic stage, and presence of IMA lymph node metastasis were independently associated with disease-free survival. Systemic recurrence rate was significantly higher in the IMA-positive group than in the IMA-negative group (48.5 vs. 20.8%, respectively, p=0.001). Para-aortic nodal recurrence showed significant association with presence of IMA lymph node metastasis on multivariate analysis (hazard ratio 11.8; 95% confidence interval 2.7-52.2, p=0.001). Conclusion: Presence of IMA lymph node metastasis should be considered as a predictive factor for high systemic recurrence, and should be treated and followed up with caution for para-aortic nodal recurrence. Society of Surgical Oncology, 2010 Kang Jeonghyun Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Hur Hyuk Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Min Byung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Kim Nam Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Lee Kang Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 704-710 1068-9265 18:3<704 2011 18 10434 https://doi.org/10.1245/s10434-010-1291-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1291-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kang Jeonghyun Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Hur Hyuk Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Min Byung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Nam Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Kang Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 704-710 1068-9265 18:3<704 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer