caa a22 4500 445335084 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1331-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1331-6 Analysis of Prognostic Factors and a Proposed New Classification for Invasive Papillary Mucinous Neoplasms [Elektronische Daten] [Jin-Young Jang, Dae Hwang, Min Kim, Mee-Joo Kang, Chang Lim, Seung Lee, Sun-Whe Kim] Background: The characteristics of invasive type-intraductal papillary mucinous neoplasm (invasive IPMN) have not been fully explored due to limited reports. Furthermore, a straightforward method is needed to describe its aggressiveness. The purpose of this study was to investigate prognostic factors and to examine the clinical significance of percentage pancreatic volume occupied by the invasive component in invasive IPMN. Methods: Of 217 patients who underwent surgical resection with a diagnosis of IPMN between 2001 and 2008, 41 had invasive IPMC. We serially sectioned pancreatic parenchyma at 5-7-mm intervals. Whole slides were reviewed by a pancreas-biliary tract special pathologist, who determined the percentage pancreatic volumes occupied by the invasive components (IC%) in whole IPMN lesions. Results: By multivariate analysis, perineural invasion, metastasis, AJCC stage, and invasive component percentage (IC%) significantly predicted prognosis. IC% was found to be significantly associated with survival. Patients with an IC% <10 had a 3-year survival rate (YSR) of 100%, whereas patients with an IC% >50% had a 3 YSR of 36.5% and those with an IC% of 10-50% had a 3 YSR of 71.4% (p=0.041). Conclusions: In addition to conventional prognostic factors, such as AJCC stage and perineural invasion, the percentage of pancreatic volume occupied by the invasive component (IC%) appears to be an important prognostic factor in invasive IPMN. The concept of IC% is straightforward, semiquantitative, and objective, and offers a means of determining tumor aggressiveness; hence, it could be a means of classifying invasive IPMN. Society of Surgical Oncology, 2010 Jang Jin-Young Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut Hwang Dae Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Kim Min Department of Pathology, Seoul National University College of Medicine, Seoul, Korea aut Kang Mee-Joo Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut Lim Chang Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut Lee Seung Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea aut Kim Sun-Whe Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 644-650 1068-9265 18:3<644 2011 18 10434 https://doi.org/10.1245/s10434-010-1331-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1331-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jang Jin-Young Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Hwang Dae Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Min Department of Pathology, Seoul National University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kang Mee-Joo Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lim Chang Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Seung Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Sun-Whe Department of Surgery, Seoul National University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 644-650 1068-9265 18:3<644 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer