caa a22 4500 445335114 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1371-y doi (NATIONALLICENCE)springer-10.1245/s10434-010-1371-y Role of Survivin Gene Promoter Polymorphism (−31G>C) in Susceptibility and Survival of Esophageal Cancer in Northern India [Elektronische Daten] [Rohit Upadhyay, Rohini Khurana, Shaleen Kumar, Uday Ghoshal, Balraj Mittal] Background and Aim: Survivin is an upregulated inhibitor of apoptosis protein in esophageal cancer (EC), and a promoter region polymorphism (−31G>C) in the survivin gene has been reported as a modulator of gene expression. We aim to explore the role of survivin −31G>C polymorphism in susceptibility and survival of EC patients in northern Indian population. Materials and Methods: A case-control study was performed in 500 subjects (250 EC patients and 250 controls), and genotyping was done by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Results: Survivin CC genotype was found to be significantly associated with EC susceptibility [odds ratio (OR)=2.29; 95% confidence interval (CI)=1.27-4.14; P=0.006], particularly in males (OR=4.91; 95% CI=2.19-11.02; P=0.0001) having squamous cell carcinoma (SCC) histopathology (OR=2.4; 95% CI=1.36-4.21; P=0.002) at middle third esophagus location (OR=2.60; 95% CI=1.40-4.82; P=0.002). Patients carrying CC genotype were found to have higher susceptibility to lymph node metastasis (OR=2.82; 95% CI=1.46-5.48; P=0.002). However, on survival analysis, no prognostic role of survivin −31G>C polymorphism was detected. In case-only analysis, no gene-environment interaction was observed. Conclusion: Survivin promoter region polymorphism (−31G>C) is associated with susceptibility and clinical characteristics but not prognosis of esophageal cancer in northern Indian population. Society of Surgical Oncology, 2010 Upadhyay Rohit Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut Khurana Rohini Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut Kumar Shaleen Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut Ghoshal Uday Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut Mittal Balraj Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 880-887 1068-9265 18:3<880 2011 18 10434 https://doi.org/10.1245/s10434-010-1371-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1371-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Upadhyay Rohit Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 700 1- Khurana Rohini Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 700 1- Kumar Shaleen Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 700 1- Ghoshal Uday Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 700 1- Mittal Balraj Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 880-887 1068-9265 18:3<880 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer