caa a22 4500 445335122 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1322-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1322-7 Operative Salvage for Retroperitoneal Nodal Recurrence in Colorectal Cancer: A Systematic Review [Elektronische Daten] [Thomas Ho, Lloyd Mack, Walley Temple] Background: Retroperitoneal nodal recurrence after curative resection of colorectal cancer is an uncommon and challenging problem. The evidence for salvage surgery is limited and remains controversial, particularly when major vascular structures are involved. Some reports have demonstrated a survival benefit after metachronous resection of retroperitoneal metastasis with and without concomitant aortic resection. We conducted a systematic review of the literature to find evidence in favor of or against salvage surgery. Methods: Electronic searches of the MEDLINE, Cochrane, and EMBASE database were performed. Additional papers were identified by a manual search of the references from the key articles. Only peer-reviewed articles published in the English language were evaluated. Results: A total of nine suitable studies were identified: three case reports and six larger series, of which one was a case-control study. Including our case reports, the total number of patients who underwent surgical resection that are available for review was 110. Median overall survival was between 34 and 44months and median disease-free survival between 17 and 21months. Concomitant resection of major vessels with graft replacement was feasible with survival ranging from 19months to 18years. There was no reported mortality associated with surgical salvage of retroperitoneal recurrence and the overall morbidity was 17-33%. Conclusions: The current literature suggests that more aggressive surgical treatment of retroperitoneal nodal recurrence in CRC has acceptable morbidity and may be associated with an improved survival in well-selected patients. Society of Surgical Oncology, 2010 Ho Thomas Surgical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada aut Mack Lloyd Surgical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada aut Temple Walley Surgical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 697-703 1068-9265 18:3<697 2011 18 10434 https://doi.org/10.1245/s10434-010-1322-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1322-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ho Thomas Surgical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Mack Lloyd Surgical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Temple Walley Surgical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 697-703 1068-9265 18:3<697 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer