caa a22 4500 445335157 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1432-2 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1432-2 Impact of uPA System Gene Polymorphisms on the Susceptibility of Environmental Factors to Carcinogenesis and the Development of Clinicopathology of Oral Cancer [Elektronische Daten] [Chia-Jui Weng, Chiao-Wen Lin, Tsung-Te Chung, Chiung-Man Tsai, Mu-Kuan Chen, Shun-Fa Yang] Background: The levels of urokinase plasminogen activator (uPA) system in tumor tissues are implicated as prognostic biomarkers in a wide range of malignancies. However, their possible impact on the risk and prognosis of oral cancer and the susceptibility of environmental carcinogens to oral cancer remains poorly investigated. Methods: The genetic polymorphisms of uPA, uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 253 patients with oral cancer and 344 healthy controls. Results: There was no significant effect of uPA system genes on the susceptibility of oral cancer; however, the impact of uPA system gene polymorphisms on the susceptibility of betel nut and tobacco consumptions to oral cancer was revealed, except for that of uPAR gene polymorphism on tobacco consumption. Patients with oral cancer with at least one 5G allele of PAI-1 gene have a low risk for the development of clinical stage III or IV (p≤0.05) and lymph node metastasis (p≤0.05) compared with those with 4G/4G homozygotes. Conclusions: Our results suggest that the combination of uPA system gene polymorphisms and environmental carcinogens was related to the risk of oral cancer, and the genetic polymorphism of PAI-1 was associated with a low risk to the clinicopathological development of oral cancer. Society of Surgical Oncology, 2010 Weng Chia-Jui Graduate Institute of Applied Science of Living, Tainan University of Technology, Tainan, Taiwan aut Lin Chiao-Wen Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan aut Chung Tsung-Te Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aut Tsai Chiung-Man Chest Hospital, Department of Health, Executive Yuan, Tainan, Taiwan aut Chen Mu-Kuan Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aut Yang Shun-Fa Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 805-812 1068-9265 18:3<805 2011 18 10434 https://doi.org/10.1245/s10434-010-1432-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1432-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weng Chia-Jui Graduate Institute of Applied Science of Living, Tainan University of Technology, Tainan, Taiwan aut NATIONALLICENCE 700 1- Lin Chiao-Wen Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan aut NATIONALLICENCE 700 1- Chung Tsung-Te Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aut NATIONALLICENCE 700 1- Tsai Chiung-Man Chest Hospital, Department of Health, Executive Yuan, Tainan, Taiwan aut NATIONALLICENCE 700 1- Chen Mu-Kuan Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aut NATIONALLICENCE 700 1- Yang Shun-Fa Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 805-812 1068-9265 18:3<805 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer