caa a22 4500 445335203 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1303-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1303-x Expression and Clinical Significance of Hepatoma-Derived Growth Factor as a Prognostic Factor in Human Hilar Cholangiocarcinoma [Elektronische Daten] [Yan-feng Liu, Rui Zhao, Sen Guo, Xian-qiang Wang, Pei-long Lian, Yue-guang Chen, Ke-sen Xu] Background: Overexpressions of hepatoma-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) play important roles in the development and progression of cancers. This study investigates the expression of HDGF combined with VEGF, their correlation with clinicopathologic features, and their prognosis in human hilar cholangiocarcinoma. Materials and Methods: The expressions of HDGF and VEGF were analyzed by immunohistochemistry using the streptavidin peroxidase complex method for 58 patients with hilar cholangiocarcinoma receiving surgery. Their correlation with clinicopathologic features was then investigated. The relationships between them and the survival time of patients were retrospectively analyzed. Results: HDGF and VEGF were positively expressed in 27 (46.6%) and 42 (72.4%) patients, respectively. HDGF and VEGF had a positive correlation (r=0.370, P=0.004) in the Spearman rank correlation analysis. HDGF expression was associated with gender and histological type. Patients with positive HDGF expression had a significantly poorer overall survival rate than those with negative HDGF expression (35.7 vs. 73.3%, P=0.003). Multivariate analysis showed that HDGF expression is an independent prognostic factor. Conclusions: HDGF expression significantly correlates with VEGF expression and is a valuable prognostic factor for human hilar cholangiocarcinoma. Society of Surgical Oncology, 2010 Liu Yan-feng Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Zhao Rui Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Guo Sen Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Wang Xian-qiang Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Lian Pei-long Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Chen Yue-guang Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Xu Ke-sen Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 872-879 1068-9265 18:3<872 2011 18 10434 https://doi.org/10.1245/s10434-010-1303-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1303-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Yan-feng Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Rui Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Guo Sen Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Wang Xian-qiang Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Lian Pei-long Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Chen Yue-guang Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Xu Ke-sen Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 872-879 1068-9265 18:3<872 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer