caa a22 4500 445335254 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1388-2 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1388-2 Preoperative Chemotherapy with Cisplatin and Docetaxel Followed by Surgery and Clip-Oriented Postoperative Chemoradiation in Patients with Localized Gastric or Gastroesophageal Junction Adenocarcinoma: Results from a Phase II Feasibility Study [Elektronische Daten] [G. Spizzo, D. Öfner, A. de Vries, P. Lukas, G. Steger, U. Pluschnig, J. Zacherl, J. Widder, A. Zabernigg, G. Gastl, G. Mühlmann] Background: We conducted a phase II feasibility study using preoperative chemotherapy with cisplatin and docetaxel followed by surgical resection and postoperative chemoradiation in patients with gastric or gastroesophageal cancer. Methods: Preoperative chemotherapy (two or three cycles) consisted of 50mg/m2 docetaxel and 50mg/m2 cisplatin. Surgical resection was planned 4weeks after the last chemotherapy cycle. Patients underwent postsurgical chemoradiation, receiving a total dose of 39.6Gy and 5-fluorouracil (5-FU) continuous infusion (350mg/m2/day). The primary end-points were feasibility, overall response rate and R0 resectability rate after preoperative chemotherapy. The secondary end-points were tolerability, treatment-associated complications, disease-free survival and overall survival. Results: Between 2002 and 2004, 15 patients were enrolled in this study. After neoadjuvant treatment, two patients (13%) experienced progressive disease, four patients (27%) showed partial remission and nine patients (60%) showed stable disease. In 11 patients (73%) R0 resectability could be achieved. Six of these patients (54%) were able to undergo postoperative chemoradiation. Notably, five (83%) of these patients were disease free and alive at median follow-up of 72months. Chemotherapy-associated neutropaenia and neutropaenic fever, anastomotic dehiscence, pulmonary embolism and acute pancreatitis were observed. Conclusions: The combination of preoperative chemotherapy and postoperative chemoradiation is feasible in a significant subset of gastric cancer patients. Society of Surgical Oncology, 2010 Spizzo G. Division of Haematology and Oncology, Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria aut Öfner D. Department of Surgery, Paracelsus Private Medical University, Salzburger Landeskliniken, Salzburg, Austria aut de Vries A. Department of Therapeutic Radiology and Oncology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria aut Lukas P. Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria aut Steger G. Division of Oncology, Department of Internal Medicine, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut Pluschnig U. Division of Oncology, Department of Internal Medicine, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut Zacherl J. Division of General Surgery, Department of Surgery, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut Widder J. Department of Radiotherapy, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut Zabernigg A. Department of Internal Medicine, General Hospital Kufstein, Kufstein, Austria aut Gastl G. Division of Haematology and Oncology, Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria aut Mühlmann G. Center of Operative Medicine, Department of Visceral - Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 677-683 1068-9265 18:3<677 2011 18 10434 https://doi.org/10.1245/s10434-010-1388-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1388-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spizzo G. Division of Haematology and Oncology, Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria aut NATIONALLICENCE 700 1- Öfner D. Department of Surgery, Paracelsus Private Medical University, Salzburger Landeskliniken, Salzburg, Austria aut NATIONALLICENCE 700 1- de Vries A. Department of Therapeutic Radiology and Oncology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria aut NATIONALLICENCE 700 1- Lukas P. Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria aut NATIONALLICENCE 700 1- Steger G. Division of Oncology, Department of Internal Medicine, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Pluschnig U. Division of Oncology, Department of Internal Medicine, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Zacherl J. Division of General Surgery, Department of Surgery, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Widder J. Department of Radiotherapy, Medical University of Vienna, General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Zabernigg A. Department of Internal Medicine, General Hospital Kufstein, Kufstein, Austria aut NATIONALLICENCE 700 1- Gastl G. Division of Haematology and Oncology, Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria aut NATIONALLICENCE 700 1- Mühlmann G. Center of Operative Medicine, Department of Visceral - Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 677-683 1068-9265 18:3<677 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer