caa a22 4500 445335297 CHVBK 20180317142752.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1245/s10434-010-1354-z doi (NATIONALLICENCE)springer-10.1245/s10434-010-1354-z Diagnostic Value of BRAFV600E Mutation Analysis of Thyroid Nodules According to Ultrasonographic Features and the Time of Aspiration [Elektronische Daten] [Hee Moon, Eun-Kyung Kim, Woong Chung, Jong Choi, Jung Yoon, Jin Kwak] Background: We investigated the diagnostic value of the BRAFV600E mutation of thyroid nodules according to ultrasonography (US) features and the time of BRAFV600E mutation analysis. Methods: A total of 304 nodules in 295 patients (mean age, 49.4years) were included. Thyroid nodules were classified as suspicious or probably benign on US. Group 1 (n=168) included nodules with BRAFV600E mutation analysis at the time of the initial US-guided fine needle aspiration biopsy (US-FNAB) and group 2 (n=136) included nodules with analysis at the time of the repeat US-FNAB. The frequency of malignancy and the BRAFV600E mutation were compared between suspicious and probably benign nodules on US and between groups 1 and 2. Results: Of 304 nodules, 113 were malignant and 59 (52.2%) had the BRAFV600E mutation. Also, 58 of 196 nodules suspicious on US (29.6%) had the BRAFV600E mutation, whereas 1 of 108 (0.9%) probably benign nodules had the BRAFV600E mutation (P value <.0001). The BRAFV600E mutation was more frequently found in nodules suspicious on US than those probably benign in both groups 1 and 2 (P value <.0001 and .0058, respectively). Preoperative detection of the BRAFV600E mutation led surgeons to perform surgery in 5.8% of 103 nodules with benign and nondiagnostic results on cytology in group 1 and 1% of 98 nodules in group 2 without treatment delay. Conclusions: The BRAFV600E mutation analysis was a useful adjunctive diagnostic tool, especially in nodules suspicious on US, and was more effective if performed at the time of the initial US-FNAB. Society of Surgical Oncology, 2010 Moon Hee Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Kim Eun-Kyung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Chung Woong Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Choi Jong Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea aut Yoon Jung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Kwak Jin Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 792-799 1068-9265 18:3<792 2011 18 10434 https://doi.org/10.1245/s10434-010-1354-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1354-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moon Hee Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Eun-Kyung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Woong Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Jong Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Yoon Jung Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kwak Jin Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/3(2011-03-01), 792-799 1068-9265 18:3<792 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer