caa a22 4500 445335408 CHVBK 20180317142753.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1643-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1643-1 Low-Dose Preoperative Chemoradiation Therapy Compared with Surgery Alone with or Without Postoperative Radiotherapy in Patients with Head and Neck Carcinoma [Elektronische Daten] [Thomas Mücke, Mario Konen, Stefan Wagenpfeil, Marco Kesting, Klaus-Dietrich Wolff, Frank Hölzle] Background: Several multimodal strategies have been developed to treat patients with squamous cell carcinoma of the oral cavity (OSCC), and many have shown survival benefits. The theoretical advantages of preoperative chemoradiotherapy are downstaging of the primary tumor, an increased resectability rate, and the elimination of micrometastases. We aimed to assess whether a short low-dose preoperative radiotherapy regimen with concurrent low-dose chemotherapy with cisplatin improves outcomes for patients with OSCC undergoing surgical treatment with curative intent. Methods: A total of 407 patients received preoperative low-dose radiotherapy of 20Gy given in 10 fractions with concurrent low-dose chemotherapy with cisplatin (12.5mg/m2) as part of a pre-existing protocol. This was compared with 519 patients receiving surgery alone. Endpoints were overall survival, tumor response, and toxic effects. Analysis was controlled for tumor-related and demographic factors. Results: After controlling for age, tumor stage, nodal stage, tumor grade, recurrence, and resection margin status, which were independent and dependent predictors of survival, preoperative radiotherapy was associated with improved survival [0.79; P=0.002; 95% confidence interval (95% CI), 0.66-0.96], in patients receiving only preoperative radiation therapy or in combination with/without postoperative radiotherapy (1.31; P=0.041; 95% CI, 1.01-1.70 with postoperative radiotherapy; 1.40; P=0.039; 95% CI, 1.01-1.85 without postoperative radiotherapy). Conclusions: Low-dose preoperative radiotherapy combined with low-dose chemotherapy with cisplatin significantly improves overall survival for patients with resectable OSCC compared with surgery alone. Society of Surgical Oncology, 2011 Mücke Thomas Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut Konen Mario Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut Wagenpfeil Stefan Institute for Medical Statistics and Epidemiology, Technische Universität München, München, Germany aut Kesting Marco Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut Wolff Klaus-Dietrich Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut Hölzle Frank Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2739-2747 1068-9265 18:10<2739 2011 18 10434 https://doi.org/10.1245/s10434-011-1643-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1643-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mücke Thomas Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut NATIONALLICENCE 700 1- Konen Mario Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut NATIONALLICENCE 700 1- Wagenpfeil Stefan Institute for Medical Statistics and Epidemiology, Technische Universität München, München, Germany aut NATIONALLICENCE 700 1- Kesting Marco Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut NATIONALLICENCE 700 1- Wolff Klaus-Dietrich Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut NATIONALLICENCE 700 1- Hölzle Frank Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2739-2747 1068-9265 18:10<2739 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer