caa a22 4500 445335440 CHVBK 20180317142753.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1707-2 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1707-2 Ductal Carcinoma-In-Situ of the Breast with Subsequent Distant Metastasis and Death [Elektronische Daten] [Robert Roses, Banu Arun, Sara Lari, Elizabeth Mittendorf, Anthony Lucci, Kelly Hunt, Henry Kuerer] Background: The rare patient diagnosed with pure ductal carcinoma-in-situ (DCIS) develops distant breast cancer metastases (DM). We sought to identify clinical and pathologic predictors of DM. Methods: The clinical and pathologic characteristics of patients with DM after a diagnosis of pure DCIS from 1996 to 2009 were analyzed. Results: Twenty five patients with DM after an initial diagnosis of DCIS were identified; 3 were treated at our institution and 22 were originally treated elsewhere. The rate of DM was 0.14% among 2,123 patients originally treated at our institution. Among all patients with DM, 73.7% had DCIS with necrosis, and 62% had DCIS that did not express estrogen receptor. Twenty-four percent of patients with DM were African American, compared to 11.5% of the total study population. The median time from DCIS to DM was 4.5years. Sixteen patients (66%) had a preceding or simultaneous invasive locoregional recurrence (LRR); nine (34%) did not. At last follow-up, 14 patients (56%) had died of disease; median time to death was 2.4years. No dominant variables could be identified in patients who developed DM with or without a LRR. Conclusions: DM after a diagnosis of pure DCIS is rare. Although most patients with DM have a preceding invasive LRR, some present with subsequent DM alone. Further study is required to identify clinical and pathologic predictors of this more rapid disease progression. Society of Surgical Oncology, 2011 Roses Robert Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Arun Banu Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Lari Sara Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Mittendorf Elizabeth Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Lucci Anthony Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Hunt Kelly Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Kuerer Henry Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2873-2878 1068-9265 18:10<2873 2011 18 10434 https://doi.org/10.1245/s10434-011-1707-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1707-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roses Robert Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Arun Banu Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Lari Sara Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Mittendorf Elizabeth Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Lucci Anthony Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Hunt Kelly Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Kuerer Henry Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2873-2878 1068-9265 18:10<2873 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer