caa a22 4500 445335459 CHVBK 20180317142753.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1669-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1669-4 The Negative Effect of Triple-Negative Breast Cancer on Outcome after Breast-Conserving Therapy [Elektronische Daten] [Sandra Zaky, MaryJo Lund, Kelly May, Karen Godette, Jonathan Beitler, Leslie Holmes, Ruth O'Regan, Esther Yu, David Yu, Jerome Landry] Purpose: To evaluate disease failure patterns and overall survival (OS) of women with triple-negative (TN) breast cancer who underwent breast-conserving therapy (BCT) and to understand the relationship of TN tumors with other prognostic factors. Patients and Methods: The Surveillance, Epidemiology, and End Results (SEER) registry identified 562 women diagnosed and/or treated with unilateral invasive breast cancer during 2003-2004 at three Emory hospitals. After medical record review, 193 eligible women, with all tumor types, received BCT. Primary endpoints (local, regional, and distant recurrences) and secondary endpoint (OS) were evaluated using chi-square tests and Cox proportional hazards models. Results: Of the 193 women, 33 (17.1%) had TN tumors and 160 (82.9%) had non-TN tumors. Patient characteristics were similar between the two tumor types; however, tumor grade and use of chemotherapy and hormones differed between the two groups. Median follow-up was 3.4years; 22 patients had recurrence (12.2%), and 12 died (6.2%). Patients with TN tumors had higher local (12% versus 4% for non-TN) and distant recurrences (15% versus 4% for non-TN) rates (p=0.01). On multivariate survival analyses, TN status [hazard ratio (HR) 1.8, 95% confidence interval (CI) 1.13-2.93] and African American (AA) race (HR 1.9, 95%CI 1.2-3.07) were independent predictors of inferior OS. Conclusions: Patients with TN breast cancer showed significant increases in local and distant metastatic recurrence rates after BCT, and TN status and AA race were independent negative predictors of survival. For the future, identification of these high risk features may bring personalized medicine closer to reality. Society of Surgical Oncology, 2011 Zaky Sandra Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Lund MaryJo Departments of Epidemiology and Hematology/Oncology (Joint), Rollins School of Public Health & Emory School of Medicine, Emory University Winship Cancer Center, Atlanta, GA, USA aut May Kelly Department of Hematology/Medical Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Godette Karen Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Beitler Jonathan Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Holmes Leslie Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut O'Regan Ruth Department of Hematology/Medical Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Yu Esther Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Yu David Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Landry Jerome Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2858-2865 1068-9265 18:10<2858 2011 18 10434 https://doi.org/10.1245/s10434-011-1669-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1669-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zaky Sandra Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Lund MaryJo Departments of Epidemiology and Hematology/Oncology (Joint), Rollins School of Public Health & Emory School of Medicine, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- May Kelly Department of Hematology/Medical Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Godette Karen Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Beitler Jonathan Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Holmes Leslie Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- O'Regan Ruth Department of Hematology/Medical Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Yu Esther Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Yu David Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Landry Jerome Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2858-2865 1068-9265 18:10<2858 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer