caa a22 4500 445335564 CHVBK 20180317142753.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1819-8 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1819-8 Is the Clinical Risk Score for Patients with Colorectal Liver Metastases Still Useable in the Era of Effective Neoadjuvant Chemotherapy? [Elektronische Daten] [Ninos Ayez, Zarina Lalmahomed, Anne van der Pool, Yvonne Vergouwe, Kees van Montfort, Jeroen de Jonge, Alexander Eggermont, Jan IJzermans, Cornelis Verhoef] Background: Several clinical risk scores (CRSs) for the outcome of patients with colorectal liver metastases have been validated, but not in patients undergoing neoadjuvant chemotherapy. Therefore, this study evaluates the predictive value of these CRSs in this specific group. Methods: Between January 2000 and December 2008, all patients undergoing a metastasectomy were analyzed and divided into two groups: 193 patients did not receive neoadjuvant chemotherapy (group A), and 159 patients received neoadjuvant chemotherapy (group B). In group B, the CRSs were calculated before and after administration of neoadjuvant chemotherapy. Results were evaluated by using the CRSs proposed by Nordlinger et al., Fong et al., Nagashima et al., and Konopke et al. Results: In groups A and B, the overall median survival was 43 and 47months, respectively (P=0.648). In group A, all CRSs used were of statistically significant predictive value. Before administration of neoadjuvant chemotherapy, only the Nordlinger score was of predictive value. After administration of neoadjuvant chemotherapy, all CRSs were of predictive value again, except for the Konopke score. Conclusions: Traditional CRSs are not a reliable prognostic tool when used in patients before treatment with neoadjuvant chemotherapy. However, CRSs assessed after the administration of neoadjuvant chemotherapy are useful to predict prognosis. The Author(s), 2011 Ayez Ninos Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Lalmahomed Zarina Division of Transplantation and Hepatobiliary Surgery, Erasmus University MC, Rotterdam, The Netherlands aut van der Pool Anne Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Vergouwe Yvonne Division of Public Health, Center for Medical Decision Making, Rotterdam, The Netherlands aut van Montfort Kees Division of Biostatistics, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut de Jonge Jeroen Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Eggermont Alexander Institut de cancérologie Gustav Roussy, Villejuif, France aut IJzermans Jan Division of Transplantation and Hepatobiliary Surgery, Erasmus University MC, Rotterdam, The Netherlands aut Verhoef Cornelis Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2757-2763 1068-9265 18:10<2757 2011 18 10434 https://doi.org/10.1245/s10434-011-1819-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1819-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ayez Ninos Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Lalmahomed Zarina Division of Transplantation and Hepatobiliary Surgery, Erasmus University MC, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Pool Anne Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Vergouwe Yvonne Division of Public Health, Center for Medical Decision Making, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Montfort Kees Division of Biostatistics, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- de Jonge Jeroen Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Eggermont Alexander Institut de cancérologie Gustav Roussy, Villejuif, France aut NATIONALLICENCE 700 1- IJzermans Jan Division of Transplantation and Hepatobiliary Surgery, Erasmus University MC, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Verhoef Cornelis Division of Surgical Oncology, Erasmus University MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2757-2763 1068-9265 18:10<2757 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer