caa a22 4500 445335572 CHVBK 20180317142753.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1712-5 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1712-5 Risk Factors that Influence Early Death Due to Cancer Recurrence After Extended Radical Esophagectomy with Three-Field Lymph Node Dissection [Elektronische Daten] [Shin-ichi Kosugi, Tatsuo Kanda, Kazuhito Yajima, Takashi Ishikawa, Katsuyoshi Hatakeyama] Background: Extended radical esophagectomy with three-field lymph node dissection (3-FLD) has offered significant survival benefit, but some patients still suffer from early recurrence and die within 1year after surgery. The purpose of this study was to identify the risk factors that influence early death due to cancer recurrence after extended radical esophagectomy with 3-FLD. Methods: A consecutive series of 276 patients who underwent extended radical esophagectomy with 3-FLD was retrospectively reviewed. Excluding patients who underwent incomplete resection or died of other diseases within 1year, we compared the clinicopathological characteristics between 203 patients who survived more than 1year (1-year survival group) and 27 who died of cancer recurrence within 1year (early-death group) by univariate and multivariate analysis. Results: Sixty-six patients (32.5%) had recurrent disease in the 1-year survival group. Hematogenous recurrences were more frequent in the early-death group than in the 1-year survival group (41% vs. 26%, respectively, p=0.0481). There was a significant difference in nodal status, number of metastatic nodes, pathological stage, vessel invasion, and intramural metastasis, and there was borderline significance in the difference of depth of invasion and histological type between the two groups by univariate analysis. Multivariate analysis demonstrated that intramural metastasis was an independent risk factor. Conclusions: Patients with intramural metastasis have a significant risk of early death even after extended radical esophagectomy with 3-FLD; however, it remains unknown whether surgical intervention can play a significant role for these patients. Society of Surgical Oncology, 2011 Kosugi Shin-ichi Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut Kanda Tatsuo Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut Yajima Kazuhito Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut Ishikawa Takashi Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut Hatakeyama Katsuyoshi Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2961-2967 1068-9265 18:10<2961 2011 18 10434 https://doi.org/10.1245/s10434-011-1712-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1712-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kosugi Shin-ichi Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut NATIONALLICENCE 700 1- Kanda Tatsuo Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut NATIONALLICENCE 700 1- Yajima Kazuhito Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut NATIONALLICENCE 700 1- Ishikawa Takashi Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut NATIONALLICENCE 700 1- Hatakeyama Katsuyoshi Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2961-2967 1068-9265 18:10<2961 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer