caa a22 4500 445335629 CHVBK 20180317142754.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1685-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1685-4 Predictors of Survival in Mucosal Melanoma of the Head and Neck [Elektronische Daten] [Daniel Jethanamest, Peter Vila, Andrew Sikora, Luc Morris] Background: The head and neck is the most common site of mucosal melanoma, a cancer with poor prognosis. In contrast to cutaneous melanoma, mucosal melanoma of the head and neck (MMHN) is uncommon, with limited data regarding outcomes and prognostic factors drawn from small, single-institution case series. In order to identify factors predictive of survival, we analyzed MMHN outcomes in a large US cohort. Methods: MMHN cases (n=815) diagnosed in the USA between 1973 and 2007 were analyzed in the Surveillance, Epidemiology, and End Results registry, and cause of death was individually determined in 778 (95.5%) cases. Kaplan-Meier survival analysis and Cox proportional hazards regression were used to analyze prognostic variables. Results: Disease-specific survival status was determined in 778 (95.5%) cases. The 5- and 10-year rates of overall survival (OS) were 25.2 and 12.2%; disease-specific survival (DSS), 32.4 and 19.3%. On multivariable analysis, anatomic primary site was an independent predictor of OS and DSS, with tumors in the nasal cavity and oral cavity associated with survival superior to tumors in the nasopharynx and paranasal sinuses. Age>70years, tumor size, nodal status, and distant metastasis status were additional independent predictors of poorer survival. Conclusions: In this large cohort of patients with MMHN, we have identified several novel factors robustly predictive of overall and melanoma-specific survival. Society of Surgical Oncology, 2011 Jethanamest Daniel Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA aut Vila Peter Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA aut Sikora Andrew Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA aut Morris Luc Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2748-2756 1068-9265 18:10<2748 2011 18 10434 https://doi.org/10.1245/s10434-011-1685-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1685-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jethanamest Daniel Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA aut NATIONALLICENCE 700 1- Vila Peter Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA aut NATIONALLICENCE 700 1- Sikora Andrew Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA aut NATIONALLICENCE 700 1- Morris Luc Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2748-2756 1068-9265 18:10<2748 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer