caa a22 4500 445335653 CHVBK 20180317142754.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1652-0 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1652-0 Tumor Size and Depth Predict Rate of Lymph Node Metastasis and Utilization of Lymph Node Sampling in Surgically Managed Gastric Carcinoids [Elektronische Daten] [Mandeep Saund, Riad Al Natour, Ashish Sharma, Qin Huang, Valia Boosalis, Jason Gold] Background: Radical resection with regional lymphadenectomy is recommended for all sporadic gastric carcinoids. Local resection, however, is accepted for some carcinoids from other gastrointestinal sites (i.e., appendix and rectum). We sought to examine the relation of tumor size and depth to lymph node metastasis to determine whether gastric carcinoids can be selected for endoscopic resection. We also sought to quantify the utilization of lymph node sampling. Methods: 984 patients with localized gastric carcinoids who underwent cancer-directed surgery between 1983 and 2005 were identified from the Surveillance, Epidemiology, and End Results (SEER) registry database. Results: Tumor size and depth predicted probability of lymph node metastasis. Lymph node metastasis was not seen in intraepithelial (IE) tumors<2cm. Of tumors<1cm invading into the lamina propria or submucosa (LP/SM), 3.4% had lymph node metastasis. Excluding IE tumors<2cm and LP/SM tumors<1cm, all other subgroups based on size and depth had rates of lymph node metastasis≥8%. Tumor size and depth predicted probability of lymph node sampling. Overall, only 21% of tumors had lymph node sampling. Excluding IE tumors<2cm and LP/SM tumors<1cm, only 43% of tumors had lymph node sampling. Conclusions: Tumor size and depth predict lymph node metastasis for gastric carcinoids. Endoscopic resection may be appropriate for intraepithelial (IE) tumors<2cm and perhaps tumors<1cm invading into the lamina propria or submucosa. Lymph node sampling is underused for gastric carcinoids at high risk for lymph node metastasis. Society of Surgical Oncology, 2011 Saund Mandeep Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA aut Al Natour Riad Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA aut Sharma Ashish Medicine Service, VA Boston Healthcare System, West Roxbury, USA aut Huang Qin Brigham and Women's Hospital, Harvard Medical School, Boston, USA aut Boosalis Valia Medicine Service, VA Boston Healthcare System, West Roxbury, USA aut Gold Jason Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2826-2832 1068-9265 18:10<2826 2011 18 10434 https://doi.org/10.1245/s10434-011-1652-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1652-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saund Mandeep Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA aut NATIONALLICENCE 700 1- Al Natour Riad Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA aut NATIONALLICENCE 700 1- Sharma Ashish Medicine Service, VA Boston Healthcare System, West Roxbury, USA aut NATIONALLICENCE 700 1- Huang Qin Brigham and Women's Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Boosalis Valia Medicine Service, VA Boston Healthcare System, West Roxbury, USA aut NATIONALLICENCE 700 1- Gold Jason Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2826-2832 1068-9265 18:10<2826 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer