caa a22 4500 445335688 CHVBK 20180317142754.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1694-3 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1694-3 Sentinel Lymph Node Biopsy in Multicentric Breast Cancer: Five-Year Results in a Large Series from a Single Institution [Elektronische Daten] [Oreste Gentilini, Paolo Veronesi, Edoardo Botteri, Fiammetta Soggiu, Giuseppe Trifirò, Germana Lissidini, Viviana Galimberti, Simona Musmeci, Paola Raviele, Antonio Toesca, Silvia Ratini, Andres Castillo, Marco Colleoni, Nina Talakhadze, Nicole Rotmensz, Giuseppe Viale, Umberto Veronesi, Alberto Luini] Purpose: This study was designed to present the 5-year results of patients with multicentric breast cancer who underwent sentinel lymph node biopsy (SLNB) in a single institution. Methods: Between June 1999 and December 2007, 337 patients with multicentric breast cancer and a clinically negative axilla underwent lymphatic mapping by a single periareolar/peritumoral (n=306) or a double peritumoral or subdermal injection (n=31) of 99mTc-HSA nanocolloids. The sentinel lymph node (SLN) was evaluated by intraoperative frozen section and axillary dissection was performed only in cases of positive SLNB. Results: The median age of the patients was 48 (range, 22-81) years. The mean number of hot spots identified was 1.4 in the whole series, 1.3 in patients who received a single injection, and 1.7 in those who received a double injection (P<0.001). The mean number of removed SLNs was 1.7 (median, 1; range, 1-7) with an identification rate of 100%. A total of 138 patients with negative SLNB (n=134) or isolated tumor cells in the SLN (n=4) did not receive completion axillary lymph node dissection (CALND). In these latter patients, a total of 27 events (19.5%) occurred with 3 patients (2.2%) developing axillary recurrences after a median follow-up of 5years (range, 17-134months). Conclusions: Axillary lymph node reappearancewas infrequent among patients withmulticentric breast cancer, having negative SLNB and no CALND. We recommend SLNB as the standard procedure for nodal staging in patients with multicentric breast cancer and a clinically negative axilla. Society of Surgical Oncology, 2011 Gentilini Oreste Division of Senology, European Institute of Oncology, Milano, Italy aut Veronesi Paolo Division of Senology, European Institute of Oncology, Milano, Italy aut Botteri Edoardo Division of Epidemiology and Biostatistics, European Institute of Oncology, Milano, Italy aut Soggiu Fiammetta Division of Senology, European Institute of Oncology, Milano, Italy aut Trifirò Giuseppe Nuclear Medicine Department, European Institute of Oncology, Milano, Italy aut Lissidini Germana Division of Senology, European Institute of Oncology, Milano, Italy aut Galimberti Viviana Division of Senology, European Institute of Oncology, Milano, Italy aut Musmeci Simona Division of Senology, European Institute of Oncology, Milano, Italy aut Raviele Paola Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milano, Italy aut Toesca Antonio Division of Senology, European Institute of Oncology, Milano, Italy aut Ratini Silvia Division of Senology, European Institute of Oncology, Milano, Italy aut Castillo Andres Division of Senology, European Institute of Oncology, Milano, Italy aut Colleoni Marco Department of Medical Oncology, European Institute of Oncology, Milano, Italy aut Talakhadze Nina Division of Senology, European Institute of Oncology, Milano, Italy aut Rotmensz Nicole Division of Epidemiology and Biostatistics, European Institute of Oncology, Milano, Italy aut Viale Giuseppe University of Milan School of Medicine, European Institute of Oncology, Milano, Italy aut Veronesi Umberto Division of Senology, European Institute of Oncology, Milano, Italy aut Luini Alberto Division of Senology, European Institute of Oncology, Milano, Italy aut Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2879-2884 1068-9265 18:10<2879 2011 18 10434 https://doi.org/10.1245/s10434-011-1694-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1694-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gentilini Oreste Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Veronesi Paolo Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Botteri Edoardo Division of Epidemiology and Biostatistics, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Soggiu Fiammetta Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Trifirò Giuseppe Nuclear Medicine Department, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Lissidini Germana Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Galimberti Viviana Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Musmeci Simona Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Raviele Paola Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Toesca Antonio Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Ratini Silvia Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Castillo Andres Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Colleoni Marco Department of Medical Oncology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Talakhadze Nina Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Rotmensz Nicole Division of Epidemiology and Biostatistics, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Viale Giuseppe University of Milan School of Medicine, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Veronesi Umberto Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 700 1- Luini Alberto Division of Senology, European Institute of Oncology, Milano, Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/10(2011-10-01), 2879-2884 1068-9265 18:10<2879 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer