caa a22 4500 445335793 CHVBK 20180317142754.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1218-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1218-6 Prognostic Value of Quality of Life and Pain in Patients with Locally Recurrent Rectal Cancer [Elektronische Daten] [Y. You, Halim Habiba, George Chang, Miguel Rodriguez-bigas, John Skibber] Background: Care of patients with locally recurrent rectal cancer (LRRC) requires careful patient selection. While curative resection offers survival benefits, significant trade-offs exist for the patient. Knowledge of patient-reported outcomes will help inform treatment decisions. Methods: Quality of life (QOL) and pain were prospectively assessed in 105 patients treated for LRRC at a single institution, using the validated Functional Assessment of Cancer Therapy-Colorectal (FACT-C) and Brief Pain Inventory (BPI) questionnaires. In 54 patients enrolled and followed from diagnosis of LRRC, relationship between pretreatment pain, QOL, and overall survival (OS) were examined. Results: Patients underwent curative surgical resection (C, 59%), noncurative surgery (NC, 12%) or nonsurgical treatment (NS, 28%). Median OS was 7.1, 1.4, and 1.9years, respectively (C versus NC: p<0.001; C versus NS: p=0.006; NC versus NS: p=0.261). Physical well-being QOL differed over time (p=0.042), with greatest difference between C and NC surgery patients (p=0.049). The remaining QOL domain scores and pain scores demonstrated no significant time or treatment effect. For the 54 patients assessed from diagnosis, median OS was independently predicted by treatment group (C, NC, NS: 4.3, 1.7, versus 2.4years; p<0.001) and pretreatment pain intensity (score≤4 versus>4: 3.8 versus 2.0years; p=0.001). Conclusion: Curative surgery offered prolonged survival, but significant pain exists among long-term survivors and should be a focus of survivorship care. Noncurative surgery did not offer apparent advantages over nonsurgical palliation. Patient's pretreatment pain has prognostic value, and should be assessed, treated, and considered in treatment decisions. Society of Surgical Oncology, 2010 You Y. Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut Habiba Halim Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut Chang George Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut Rodriguez-bigas Miguel Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut Skibber John Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 989-996 1068-9265 18:4<989 2011 18 10434 https://doi.org/10.1245/s10434-010-1218-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1218-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- You Y. Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Habiba Halim Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Chang George Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Rodriguez-bigas Miguel Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Skibber John Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 989-996 1068-9265 18:4<989 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer