caa a22 4500 445335831 CHVBK 20180317142754.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1447-8 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1447-8 Is Silver Nitrate Pleurodesis for Patients with Malignant Pleural Effusion Feasible and Safe When Performed in an Outpatient Setting? [Elektronische Daten] [Ricardo Terra, So Kim, Paulo Pego-Fernandes, Lisete Teixeira, Francisco Vargas, Fabio Jatene] Background: The purpose of this study was to analyze the effectiveness and safety of silver nitrate pleurodesis (SNP) in patients with recurrent malignant pleural effusion (RMPE) when performed in an outpatient setting. Materials and Methods: Prospective study including patients with RMPE recruited in a tertiary university-based hospital from February 2008 to June 2009. Elected patients underwent pleural catheter insertion (Day 1) followed by 0.5% SNP (Day 2), and on 7th day the drain was removed. All procedures were performed in an outpatient facility. Pleurodesis was considered successful when no additional pleural procedure was necessary by the 30th day. Complications were registered and graded according to the CTCAE3.0. Quality of life was evaluated before and 30days after SNP. Results: A total of 68 patients (54 female, 14 male, mean age: 57.3years) were included. In addition, 7 had bilateral pleural effusions; therefore, 75 hemithoraces were drained. Also, 5 were excluded, and 70 hemithoraces (63 patients) underwent SNP. During the period of 30days postpleurodesis, 8 deaths not related to the procedure occurred, and we lost contact with 10 patients who were followed elsewhere. At the 30th day, 48 hemithoraces (45 patients) were reevaluated, and 2 recurrences observed. The most frequent complication was pain—graded as 3 or more in 7 patients; infection occurred in 2 patients. Physical and environmental aspects of quality of life improved significantly after pleurodesis. Conclusions: In this study, SNP could be performed safely in an outpatient setting, with pain the most frequent complication. Recurrences occurred in 4% of the patients. Society of Surgical Oncology, 2010 Terra Ricardo Thoracic Surgery Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut Kim So University of São Paulo Medical School, São Paulo, Brazil aut Pego-Fernandes Paulo Thoracic Surgery Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut Teixeira Lisete Pulmonology Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut Vargas Francisco Pulmonology Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut Jatene Fabio Thoracic Surgery Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1145-1150 1068-9265 18:4<1145 2011 18 10434 https://doi.org/10.1245/s10434-010-1447-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1447-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terra Ricardo Thoracic Surgery Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Kim So University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Pego-Fernandes Paulo Thoracic Surgery Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Teixeira Lisete Pulmonology Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Vargas Francisco Pulmonology Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Jatene Fabio Thoracic Surgery Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1145-1150 1068-9265 18:4<1145 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer