caa a22 4500 44533584X CHVBK 20180317142754.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1410-8 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1410-8 Relationship Between Preoperative Comorbidity, Systemic Inflammatory Response, and Survival in Patients Undergoing Curative Resection for Colorectal Cancer [Elektronische Daten] [C. Roxburgh, J. Platt, E. Leitch, J. Kinsella, P. Horgan, D. McMillan] Background: Besides tumor characteristics, colorectal cancer (CRC) outcomes are also determined by host factors, in particular the systemic inflammatory response. The basis of this relationship with survival is not known; however, systemic inflammation may reflect comorbidity. The present study examines relationships between host factors (including age, comorbidity, deprivation, and systemic inflammation) and survival in CRC. Methods: A total of 302 patients underwent curative elective CRC resection between 1997 and 2005. Data was collected on patient comorbidity (Charlson Comorbidity Index [CCI], Lee Cardiac Risk Index [LCRI], National Institute on Aging and National Cancer Institute Comorbidity Index [NIA/NCI], and Adult Comorbidity Evaluation-27 [ACE-27]), systemic inflammatory response (Glasgow Prognostic Score [mGPS]), deprivation [Carstairs Deprivation Index], body mass index, and smoking status. Results: For cancer-specific survival, age (P=0.047), tumor, node, metastasis system stage (P<0.001), high-risk Petersen Index (P<0.001), LCRI (P=0.021), and mGPS (P<0.001) were independent factors by multivariate analysis. For overall survival, age (P<0.001), tumor, node, metastasis system stage (P=0.001), high-risk Petersen Index (P=0.002), postoperative infective complications (P=0.002), ACE-27 (P=0.008), and mGPS (P<0.001) were independent factors. Older age related to increasing comorbidity (ACE-27, CCI, LCRI [P<0.005]) and increased mGPS (P<0.005). Smoking and deprivation related to increasing comorbidity (P<0.05). The mGPS was associated with high comorbidity burden assessed with ACE-27 (P=0.065), CCI (P=0.016), LCRI (P=0.095), and NIA/NCI (P=0.084). Conclusions: Comorbidity does not fully explain the relationship between the mGPS and cancer-specific survival in CRC patients. Furthermore, comorbidity, in particular that measured by the LCRI, is an important independent indicator of cancer survival. Society of Surgical Oncology, 2010 Roxburgh C. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut Platt J. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut Leitch E. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut Kinsella J. University Department of Anaesthesia, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, Scotland, UK aut Horgan P. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut McMillan D. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 997-1005 1068-9265 18:4<997 2011 18 10434 https://doi.org/10.1245/s10434-010-1410-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1410-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roxburgh C. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Platt J. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Leitch E. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Kinsella J. University Department of Anaesthesia, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Horgan P. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- McMillan D. University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 997-1005 1068-9265 18:4<997 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer