caa a22 4500 445335947 CHVBK 20180317142755.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1424-2 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1424-2 Comparison of the 6th and 7th Editions of the UICC TNM Staging System for Gastric Cancer: Results of a Chinese Single-Institution Study of 1,503 Patients [Elektronische Daten] [Wei Wang, Xiao-wei Sun, Chao-feng Li, Lin Lv, Yuan-fang Li, Ying-bo Chen, Da-zhi Xu, Rajiv Kesari, Chun-yu Huang, Wei Li, You-qing Zhan, Zhi-wei Zhou] Aim: To evaluate the prognostic efficacy of the 7th edition tumor-node-metastasis (TNM) classification compared with the 6th edition in gastric cancer patients. Methods: A total of 1,503 gastric cancer patients undergoing surgical resection were staged using the 6th and 7th edition staging systems. Homogeneity, discriminatory ability, and monotonicity of gradients of the two systems were compared using linear trend χ2, likelihood ratio χ2 statistics, and Akaike information criterion (AIC) calculations. Results: Significant differences in 5-year survival rates were observed for the T, N, and M subgroups using the 7th edition system, except for stage N2 and N3 patients in the 6th edition system. There were no significant differences in survival between IB and IIA in the 7th edition system. Patients with stage IV disease due to T4/N3 in the 6th edition system who were downstaged to stage III in the 7th edition system had significantly better survival than those who remained at stage IV. The 7th edition system had higher linear trend and likelihood ratio χ2 scores, and smaller AIC values compared with those for the 6th edition, which represented the optimum prognostic stratification. Conclusions: Our study suggests that the 7th edition system performs better than the 6th edition in several aspects. The Author(s), 2010 Wang Wei State Key Laboratory of Oncology in South China, Guangzhou, China aut Sun Xiao-wei State Key Laboratory of Oncology in South China, Guangzhou, China aut Li Chao-feng State Key Laboratory of Oncology in South China, Guangzhou, China aut Lv Lin State Key Laboratory of Oncology in South China, Guangzhou, China aut Li Yuan-fang State Key Laboratory of Oncology in South China, Guangzhou, China aut Chen Ying-bo State Key Laboratory of Oncology in South China, Guangzhou, China aut Xu Da-zhi State Key Laboratory of Oncology in South China, Guangzhou, China aut Kesari Rajiv State Key Laboratory of Oncology in South China, Guangzhou, China aut Huang Chun-yu State Key Laboratory of Oncology in South China, Guangzhou, China aut Li Wei State Key Laboratory of Oncology in South China, Guangzhou, China aut Zhan You-qing State Key Laboratory of Oncology in South China, Guangzhou, China aut Zhou Zhi-wei State Key Laboratory of Oncology in South China, Guangzhou, China aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1060-1067 1068-9265 18:4<1060 2011 18 10434 https://doi.org/10.1245/s10434-010-1424-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1424-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Wei State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Sun Xiao-wei State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Li Chao-feng State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Lv Lin State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Li Yuan-fang State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Chen Ying-bo State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Xu Da-zhi State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Kesari Rajiv State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Huang Chun-yu State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Li Wei State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Zhan You-qing State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 700 1- Zhou Zhi-wei State Key Laboratory of Oncology in South China, Guangzhou, China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1060-1067 1068-9265 18:4<1060 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer