caa a22 4500 44533598X CHVBK 20180317142755.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1399-z doi (NATIONALLICENCE)springer-10.1245/s10434-010-1399-z Clinical Significance of Melanoma Antigen-Encoding Gene-1 (MAGE-1) Expression and its Correlation with Poor Prognosis in Differentiated Advanced Gastric Cancer [Elektronische Daten] [Kyoichi Ogata, Ryuusuke Aihara, Erito Mochiki, Atsushi Ogawa, Mitsuhiro Yanai, Yoshitaka Toyomasu, Hiroyuki Ando, Tetsuro Ohno, Takayuki Asao, Hiroyuki Kuwano] Background: Melanoma antigen-encoding gene-1 (MAGE-1), a cancer/testis antigen, has been reported to be expressed in various types of cancer. We investigated the clinicopathological features and prognostic significance of MAGE-1 expression in advanced gastric cancer (AGC). Methods: Immunohistochemical staining for MAGE-1 was performed on surgical specimens obtained from 135 patients with AGC. Results: Positive expression of MAGE-1 detected in cytoplasm was observed in 44 of 135 cases (32.6%) in primary tumors and 26 of 96 (27.1%) in lymph node metastases. In noncancerous gastric tissues, apparent MAGE-1 expression was not detected. MAGE-1 in primary tumor was correlated with advanced age (P<0.001), macroscopic infiltrated type (P=0.035), and presence of vascular invasion (P=0.027). The 5-year cancer-specific survival rates of AGC patients with positive MAGE-1 expression were significantly lower than those of patients with negative MAGE-1 (positive: 31.6%, negative: 57.6%, P=0.038). On multivariate analysis, MAGE-1 expression was not an independent prognostic predictor of AGC (P=0.064). In differentiated AGC patients, MAGE-1 expression was correlated with advanced age (P=0.003), macroscopic infiltrated type (P=0.009), and presence of lymph node metastasis (P=0.033). The cancer-specific survival rates of differentiated AGC patients with positive MAGE-1 were significantly lower than those of patients with negative MAGE-1 (P=0.003). Positive MAGE-1 expression was an independent prognostic factor of differentiated AGC patients on multivariate analysis (P=0.031). Conclusions: These findings suggest that MAGE-1 protein expression can serve as a predictive marker of poor prognosis in differentiated AGC patients. Society of Surgical Oncology, 2010 Ogata Kyoichi Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Aihara Ryuusuke Department of Surgery, Saiseikai Maebashi Hospital, Maebashi, Gunma, Japan aut Mochiki Erito Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Ogawa Atsushi Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Yanai Mitsuhiro Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Toyomasu Yoshitaka Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Ando Hiroyuki Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Ohno Tetsuro Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Asao Takayuki Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Kuwano Hiroyuki Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1195-1203 1068-9265 18:4<1195 2011 18 10434 https://doi.org/10.1245/s10434-010-1399-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1399-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ogata Kyoichi Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Aihara Ryuusuke Department of Surgery, Saiseikai Maebashi Hospital, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Mochiki Erito Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Ogawa Atsushi Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Yanai Mitsuhiro Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Toyomasu Yoshitaka Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Ando Hiroyuki Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Ohno Tetsuro Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Asao Takayuki Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Kuwano Hiroyuki Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1195-1203 1068-9265 18:4<1195 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer