caa a22 4500 445336005 CHVBK 20180317142755.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1435-z doi (NATIONALLICENCE)springer-10.1245/s10434-010-1435-z Clinicopathological Assessment of Locally Recurrent Rectal Cancer and Relation to Local Re-Recurrence [Elektronische Daten] [Mamoru Uemura, Masataka Ikeda, Hirofumi Yamamoto, Kotaro Kitani, Masayoshi Tokuoka, Ken Matsuda, Yuki Hata, Tsunekazu Mizushima, Ichiro Takemasa, Mitsugu Sekimoto, Ko Hosokawa, Nariaki Matsuura, Yuichiro Doki, Masaki Mori] Background: Local re-recurrence after R0 resection of local recurrence of rectal cancer (LRRC) is not rare. The purpose of this study was to examine the pathological features of LRRC and determine the prognostic factors. Methods: Twenty-one patients underwent R0 resection of LRRC without preoperative therapy from 2000 to 2008. Tumor progression patterns were classified into three types: A, expanding type; B, infiltrating type; and C, intermediate type. Distant isolated cancer cells (DICCs) were defined as cancer cells present in isolation and at a distance (>1mm) from the tumor edge. Results: Venous invasion was identified in all but one patient (95%). DICCs were observed in 11 of 21 cases. Type A patients had a significantly lower local re-recurrence rate (0/5) compared with type B and/or C patients (11/16, P=0.012) and a significantly lower incidence of distant metastasis compared with type B and C patients (0/5 vs. 13/16, respectively; P=0.0028). Multivariate regression analysis identified venous invasion of the primary lesion (P=0.027) and tumor progression patterns (P=0.039) as independent predictors of local re-recurrence. Conclusions: The main features of LRRC were infiltrating growth, venous invasion, and DICCs. Tumor progression patterns correlated with local re-recurrence and distant metastasis. Preoperative adjuvant therapy to terminate peri-tumor cancer cells may be required for better tumor control. Society of Surgical Oncology, 2010 Uemura Mamoru Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Ikeda Masataka Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Yamamoto Hirofumi Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Kitani Kotaro Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Tokuoka Masayoshi Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Matsuda Ken Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Hata Yuki Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Mizushima Tsunekazu Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Takemasa Ichiro Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Sekimoto Mitsugu Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Hosokawa Ko Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Matsuura Nariaki Department of Pathology, School of Allied Health Science, Faculty of Medicine, Osaka University, Suita City, Osaka, Japan aut Doki Yuichiro Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Mori Masaki Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1015-1022 1068-9265 18:4<1015 2011 18 10434 https://doi.org/10.1245/s10434-010-1435-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1435-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uemura Mamoru Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Ikeda Masataka Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Yamamoto Hirofumi Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Kitani Kotaro Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Tokuoka Masayoshi Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Matsuda Ken Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Hata Yuki Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Mizushima Tsunekazu Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Takemasa Ichiro Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Sekimoto Mitsugu Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Hosokawa Ko Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Matsuura Nariaki Department of Pathology, School of Allied Health Science, Faculty of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Doki Yuichiro Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 700 1- Mori Masaki Department of Surgery; Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1015-1022 1068-9265 18:4<1015 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer