caa a22 4500 445336099 CHVBK 20180317142755.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1403-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1403-7 Are We Overtreating Papillomas Diagnosed on Core Needle Biopsy? [Elektronische Daten] [Amy Cyr, Deborah Novack, Kathryn Trinkaus, Julie Margenthaler, William Gillanders, Timothy Eberlein, Jon Ritter, Rebecca Aft] Background: Breast papillomas often are diagnosed with core needle biopsy (CNB). Most studies support excision for atypical papillomas, because as many as one half will be upgraded to malignancy on final pathology. The literature is less clear on the management of papillomas without atypia on CNB. Our goal was to determine factors associated with pathology upgrade on excision. Methods: Our pathology database was searched for breast papillomas diagnosed by CNB during the past 10years. We identified 277 charts and excluded lesions associated with atypia or malignancy on CNB. Two groups were identified: papillomas that were surgically excised (group 1) and those that were not (group 2). Charts were reviewed for the subsequent diagnosis of cancer or high-risk lesions. Appropriate statistical tests were used to analyze the data. Results: A total of 193 papillomas were identified. Eighty-two lesions were excised (42%). Caucasian women were more likely to undergo excision (p=0.03). Twelve percent of excised lesions were upgraded to malignancy. Increasing age was a predictor of upgrading, but this was not significant. Clinical presentation, lesion location, biopsy technique, and breast cancer history were not associated with pathology upgrade. Two lesions in group 2 ultimately required excision due to enlargement, and both were upgraded to malignancy. Conclusions: Twenty-four percent of papillomas diagnosed on CNB have upgraded pathology on excision—half to malignancy. All of the cancers diagnosed were stage 0 or I. For patients in whom excision was not performed, 2 of 111 papillomas were later excised and upgraded to malignancy. Society of Surgical Oncology, 2010 Cyr Amy Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut Novack Deborah Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA aut Trinkaus Kathryn Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA aut Margenthaler Julie Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut Gillanders William Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut Eberlein Timothy Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut Ritter Jon Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA aut Aft Rebecca Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 946-951 1068-9265 18:4<946 2011 18 10434 https://doi.org/10.1245/s10434-010-1403-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1403-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cyr Amy Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Novack Deborah Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Trinkaus Kathryn Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Margenthaler Julie Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Gillanders William Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Eberlein Timothy Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Ritter Jon Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Aft Rebecca Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 946-951 1068-9265 18:4<946 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer