caa a22 4500 445336145 CHVBK 20180317142755.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1445-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1445-x Surgical Approach and Oncologic Outcomes Following Multidisciplinary Management of Retrorectal Sarcomas [Elektronische Daten] [Eric Dozois, David Jacofsky, Brian Billings, Antonio Privitera, Robert Cima, Peter Rose, Franklin Sim, Scott Okuno, Michael Haddock, William Harmsen, Carrie Inwards, David Larson] Background: Retrorectal sarcomas are rare, and limited data are available on oncologic outcomes following surgery. Our aim was to evaluate outcomes in this patient population at our institution. Materials and Methods: All patients who underwent surgical resection of a malignant retrorectal/presacral sarcoma between 1985 and 2005 were identified. Data analyzed included demographics, histopathologic diagnosis, surgical morbidity and mortality, use of adjuvant therapy, local and distant recurrence, and survival. Results: A total of 37 patients were identified (20 males) with a median age of 49years (range, 22-81years). The most common histopathologic diagnosis was malignant peripheral nerve sheath tumor (n=8). Also, 22 tumors were high grade and 15 were low grade. Surgical margin status was R0 in 31 patients and R1 in 6. Adjuvant therapy was given to 26 patients. Postoperative morbidity and mortality was 57% and 3%, respectively. Median length of follow-up in 16 patients alive at last contact was 4.7years. The 5-year survival free of local (LDFS), distant (DDFS), and local or distant recurrence (DFS) was 51, 58, and 39%, respectively. Patient survival at 2, 5, and 10years was 75, 55, and 47%, respectively. Disease-free survival was not significantly associated with gender (P=.16), primary vs secondary (P=.94), R0 vs R1 resection (P=.26), low vs high tumor grade (P=.17), or the use of surgery with or without adjuvant therapy (P=.33). Conclusions: Retrorectal sarcomas are often high grade and locally advanced. Most tumors are resectable with free margins, and long-term survival may be possible in up to one-half of patients following an aggressive surgical approach. Society of Surgical Oncology, 2010 Dozois Eric Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut Jacofsky David Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA aut Billings Brian Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut Privitera Antonio Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut Cima Robert Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut Rose Peter Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA aut Sim Franklin Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA aut Okuno Scott Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA aut Haddock Michael Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA aut Harmsen William Department of Biostatistics, Mayo Clinic, Rochester, MN, USA aut Inwards Carrie Department of Pathology, Mayo Clinic, Rochester, MN, USA aut Larson David Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 983-988 1068-9265 18:4<983 2011 18 10434 https://doi.org/10.1245/s10434-010-1445-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1445-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dozois Eric Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Jacofsky David Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Billings Brian Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Privitera Antonio Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Cima Robert Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Rose Peter Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Sim Franklin Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Okuno Scott Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Haddock Michael Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Harmsen William Department of Biostatistics, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Inwards Carrie Department of Pathology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Larson David Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 983-988 1068-9265 18:4<983 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer