caa a22 4500 445336153 CHVBK 20180317142755.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1409-1 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1409-1 Effect on Outcome of Recurrence Patterns After Hepatectomy for Colorectal Metastases [Elektronische Daten] [Michael D'Angelica, Peter Kornprat, Mithat Gonen, Ronald DeMatteo, Yuman Fong, Leslie Blumgart, William Jarnagin] Background: Despite improvements in surgery and chemotherapy, most patients develop recurrence after hepatectomy for metastatic colorectal cancer. Data are lacking on the effect of these patterns on outcome. Methods: A retrospective review of a prospectively maintained hepatobiliary database was performed. Pattern and timing of recurrence and outcome after recurrence were analyzed. Univariate and multivariate analyses of factors associated with outcome after recurrence were carried out. Results: From January 1997 through May 2003, a total of 733 patients underwent hepatectomy for colorectal metastases. Of these, 637 patients (87%) were included in the analysis, and in 393 patients (62%), recurrence was documented at the time of last follow-up. Initial recurrence patterns included the following: liver only in 120 patients (31%), lung only in 107 (27%), other single sites in 49 (12%), and multiple sites in 117 (30%). Recurrence occurred within 2years of hepatectomy in 75% of patients and after 3years in 11%. Margins at hepatectomy, recurrence pattern, resected recurrence, and disease-free interval from time of colectomy to hepatic metastasis and from time of hepatectomy to recurrence were independently associated with survival as measured from the time of recurrence. Recurrence in the lung, resected recurrence, and time to recurrence after hepatectomy were associated with prolonged survival as measured from the time of hepatectomy and the time of recurrence. Conclusions: The timing and pattern of recurrence after hepatic resection for metastatic colorectal cancer are important predictors of long-term survival. Society of Surgical Oncology, 2010 D'Angelica Michael Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Kornprat Peter Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Gonen Mithat Department Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut DeMatteo Ronald Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Fong Yuman Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Blumgart Leslie Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Jarnagin William Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1096-1103 1068-9265 18:4<1096 2011 18 10434 https://doi.org/10.1245/s10434-010-1409-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1409-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D'Angelica Michael Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Kornprat Peter Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Gonen Mithat Department Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- DeMatteo Ronald Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Fong Yuman Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Blumgart Leslie Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Jarnagin William Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1096-1103 1068-9265 18:4<1096 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer