caa a22 4500 44533617X CHVBK 20180317142756.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1245/s10434-010-1404-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1404-6 Safety of Liver Resection in the Elderly: How Important Is Age? [Elektronische Daten] [S. Cho, J. Steel, A. Tsung, J. Marsh, D. Geller, T. Gamblin] Background: With the aging population, more elderly patients are being considered for hepatic resection. We investigated whether advanced age was associated with higher rate and severity of postoperative complications. Methods: A total of 75 patients aged ≥70years (group E) were matched with 75 patients aged <70years (group Y) by the extent of liver resection and by operative indications. Primary outcome measures were rates and severity of complications. Secondary outcome measures were length of hospital stay and discharge destination. Univariate analysis was also performed to identify variables associated with higher surgical risk. Results: Male-to-female ratio was 43:32 in both groups. Overall complication rates were 44 and 33.3% in group E and Y, respectively (P=0.241; odds ratio=1.57; 95% confidence interval [95% CI], 0.81-3.05). There was no mortality in both groups. The only postoperative age-related morbidity was confusion in the elderly. There was no difference in the rates of severe complications (grade ≥3) between group E and group Y (16 vs. 14.7%; P=0.744; odds ratio=1.11; 95% CI, 0.46-2.70). Median length of hospital stay were 7 and 6days, respectively (P=0.01). Nineteen percent and 1% of patients in group E and group Y were discharge to rehabilitation facilities, respectively (P=0.001). Univariate analysis showed that preoperative systemic chemotherapy and longer operative time were associated with higher morbidity in the elderly. Conclusions: Liver resection can be performed in patients aged ≥70years as safely as in younger patients. Duration and timing of systemic chemotherapy before liver resection should be optimized to minimize postoperative morbidity. Society of Surgical Oncology, 2010 Cho S. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut Steel J. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut Tsung A. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut Marsh J. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut Geller D. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut Gamblin T. Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA aut Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1088-1095 1068-9265 18:4<1088 2011 18 10434 https://doi.org/10.1245/s10434-010-1404-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1404-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cho S. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Steel J. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Tsung A. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Marsh J. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Geller D. UPMC Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Gamblin T. Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/4(2011-04-01), 1088-1095 1068-9265 18:4<1088 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer