caa a22 4500 445336250 CHVBK 20180317142756.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1579-5 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1579-5 Does Previous Head and Neck Irradiation Increase the Chance of Multigland Disease in Patients with Hyperparathyroidism? [Elektronische Daten] [Monica Woll, Rebecca Sippel, Herbert Chen] Background: Exposure to therapeutic radiation, whether used to treat lymphoma, breast cancer, or benign conditions, such as acne, is thought to cause an increased risk for thyroid and/or parathyroid neoplasia. We therefore investigated whether patients with a history of head/neck irradiation and hyperparathyroidism (HPT) had a higher incidence of multigland disease. Methods: Between November 2000 and May 2010, 1,428 patients with HPT underwent parathyroidectomy at our institution. Of these cases, 39 patients (2.7%) had a history of radiation exposure (RADRX). These 39 cases were compared with the 1,389 cases without prior exposure (NO RAD RX). Results: There were no significant differences in gender or age between the two groups. Whereas most laboratory values were similar, preoperative parathyroid hormone levels were higher in the NO RADRX patients (174±7 vs. 106±8pg/ml; P<0.001). Interestingly, the resected parathyroid glands were significantly smaller in the RADRX group compared with the NO RADRX group (511±70 vs. 790±37mg; P=0.001). No differences were noted in the recurrence rate (P=0.392). Contrary to common belief, RADRX patients did not have a significantly higher incidence of multigland disease (P=0.774). Of the 39 RADRX patients, 12 (31%) had multigland disease, whereas 398 of the 1,389 (28%) NO RADRX patients had multigland disease. Conclusions: Surgical outcomes are excellent in patients with a previous history of radiation and HPT who undergo parathyroidectomy. Previous radiation exposure does not appear to increase the likelihood of multigland disease in patients with HPT. Society of Surgical Oncology, 2011 Woll Monica Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA aut Sippel Rebecca Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA aut Chen Herbert Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2240-2244 1068-9265 18:8<2240 2011 18 10434 https://doi.org/10.1245/s10434-011-1579-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1579-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Woll Monica Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA aut NATIONALLICENCE 700 1- Sippel Rebecca Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA aut NATIONALLICENCE 700 1- Chen Herbert Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2240-2244 1068-9265 18:8<2240 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer