caa a22 4500 445336269 CHVBK 20180317142756.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1562-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1562-1 Loss of Sympathetic Nerve Fibers Around Intratumoral Arterioles Reflects Malignant Potential of Gastric Cancer [Elektronische Daten] [Hideyo Miyato, Joji Kitayama, Hironori Ishigami, Shoichi Kaisaki, Hirokazu Nagawa] Background: The role and clinical significance of the alteration of sympathetic nerve fibers (SNF) was assessed in gastric cancer. Loss of nerve fibers in malignant tumors has previously been described; however, how dysfunction of the nervous system is involved in cancer progression has not been clarified in clinical studies. Materials and Methods: The distribution of SNF was examined in 82 surgically resected gastric cancer specimens with immunohistochemical staining of tyrosine hydroxylase (TH), and the association with clinicopathological findings as well as the clinical outcome of the patients was retrospectively evaluated. Results: Arterioles in the normal gastric wall were totally covered with SNF, while the immunoreactivity to TH was markedly reduced around arterioles in cancer tissue. The degree of loss of SNF was significantly correlated with the depth of invasion (P<.0001) and lymph node metastasis (P<.0001) as well as microvessel density (MVD) (P=.0043). Moreover, patients who had tumors with marked loss of SNF showed a markedly worse clinical outcome, with an independent association by multivariate analysis. Conclusions: Loss of periarteriolar SNF is associated with aggressive phenotype of gastric cancer possibly through enhanced angiogenesis and thus could be a useful marker to predict the clinical outcome. Society of Surgical Oncology, 2011 Miyato Hideyo Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut Kitayama Joji Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut Ishigami Hironori Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut Kaisaki Shoichi Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut Nagawa Hirokazu Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2281-2288 1068-9265 18:8<2281 2011 18 10434 https://doi.org/10.1245/s10434-011-1562-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1562-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyato Hideyo Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kitayama Joji Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishigami Hironori Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kaisaki Shoichi Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagawa Hirokazu Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2281-2288 1068-9265 18:8<2281 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer