caa a22 4500 445336277 CHVBK 20180317142756.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-010-1541-y doi (NATIONALLICENCE)springer-10.1245/s10434-010-1541-y High Accuracy of Multislices Computed Tomography (MSCT) for Para-Aortic Lymph Node Metastases from Gastric Cancer: A Prospective Single-Center Study [Elektronische Daten] [Daniele Marrelli, Maria Mazzei, Corrado Pedrazzani, Marianna Di Martino, Carla Vindigni, Giovanni Corso, Eleonora Morelli, Luca Volterrani, Franco Roviello] Background: The purpose of this study is to analyze the diagnostic accuracy of MSCT in the identification of para-aortic lymph node metastases from gastric cancer. Methods: A total of 92 consecutive patients with primary gastric cancer were prospectively submitted to preoperative MSCT staging according to a standard protocol in the period 2003-2010. All diagnostic procedures were performed by dedicated radiologists who were unaware of the final pathological nodal status. Subsequently all patients underwent potentially curative (R0) resection with extended lymphadenectomy plus para-aortic nodal dissection. Lymph node mapping in different stations and retrieval of single lymph nodes were performed by the surgeon on the fresh specimen and then submitted for pathological examination. Clinical, radiological, and pathological data were prospectively stored on database. Results: A median number of 47 (range: 18-114) total lymph nodes and 7 (range: 3-29) para-aortic lymph nodes were removed. In 13 of 92 included patients (14%), histological examination demonstrated para-aortic nodal metastases; MSCT was correctly positive in 11 of these cases (sensitivity: 85%). In 79 patients para-aortic nodes were not involved, and MSCT resulted correctly negative in 75 of these patients (specificity: 95%). Positive (PPV) and negative (NPV) predictive values were 73 and 97%, with a global accuracy of 93%. Conclusions: MSCT performed according to a standard protocol by dedicated radiologists demonstrated high accuracy in preoperative identification of para-aortic nodal metastases from gastric cancer. These results may be useful in planning surgical approach or during clinical staging before neoadjuvant chemotherapy. Society of Surgical Oncology, 2011 Marrelli Daniele Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Mazzei Maria Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Pedrazzani Corrado Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Di Martino Marianna Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Vindigni Carla Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Corso Giovanni Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Morelli Eleonora Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Volterrani Luca Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Roviello Franco Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2265-2272 1068-9265 18:8<2265 2011 18 10434 https://doi.org/10.1245/s10434-010-1541-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1541-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marrelli Daniele Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Mazzei Maria Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Pedrazzani Corrado Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Di Martino Marianna Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Vindigni Carla Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Corso Giovanni Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Morelli Eleonora Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Volterrani Luca Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Roviello Franco Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2265-2272 1068-9265 18:8<2265 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer