caa a22 4500 445336366 CHVBK 20180317142756.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1595-5 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1595-5 Childbearing After Hyperthermic Intraperitoneal Chemotherapy: Results From an International Survey [Elektronische Daten] [Pablo Ortega-Deballon, Olivier Glehen, Edward Levine, Pompiliu Piso, Paul Sugarbaker, Andrea Hayes-Jordan, Audrey Facy, Naoual Bakrin, Patrick Rat] Background: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) can improve survival in selected patients with primary or secondary peritoneal malignancies. With the opportunity for long-term survival, questions about the impact of those procedures in fertility in women of childbearing age can be raised. Materials and Methods: An international survey was performed among all teams participating in the International Peritoneal Surface Malignancy Group in order to collect data about pregnancies and their outcome in women having undergone previous CRS with adjuvant HIPEC. Results: There were 7 pregnancies reported after CRS and HIPEC in women treated for peritoneal malignancies. All these women conceived spontaneously, most of them within 2years after the procedure. They delivered most often by vaginal way after an uneventful pregnancy. Their newborns were healthy, except 1 case of congenital diaphragmatic hernia requiring emergent surgery. There were 2 additional uneventful pregnancies reported after the diagnosis of pseudomyxoma peritonei and before CRS and HIPEC, with the support of the medical team. Another woman having undergone oocytes retrieval and embryo cryopreservation prior to the surgery was mother of twins after the procedure via a surrogate mother. Conclusion: Childbearing after cytoreductive surgery and heated intraperitoneal chemotherapy is possible in women conserving their genital organs after the procedure. The question of fertility should be considered and discussed in women in reproductive age prior to cytoreductive surgery and heated intraperitoneal chemotherapy. Different options could be offered in this setting. Multidisciplinary decision making involving surgical oncologists and fertility specialists is important. Society of Surgical Oncology, 2011 Ortega-Deballon Pablo INSERM UMR 866, Dijon, France aut Glehen Olivier University Hospital of Lyon South, Pierre Bénite, France aut Levine Edward Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA aut Piso Pompiliu University Medical Center of Regensburg, Regensburg, Germany aut Sugarbaker Paul Washington Cancer Institute, Columbia, Washington, DC, USA aut Hayes-Jordan Andrea MD Anderson Cancer Center, Houston, TX, USA aut Facy Audrey University Hospital of Dijon, Dijon, France aut Bakrin Naoual University Hospital of Lyon South, Pierre Bénite, France aut Rat Patrick INSERM UMR 866, Dijon, France aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2297-2301 1068-9265 18:8<2297 2011 18 10434 https://doi.org/10.1245/s10434-011-1595-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1595-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ortega-Deballon Pablo INSERM UMR 866, Dijon, France aut NATIONALLICENCE 700 1- Glehen Olivier University Hospital of Lyon South, Pierre Bénite, France aut NATIONALLICENCE 700 1- Levine Edward Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Piso Pompiliu University Medical Center of Regensburg, Regensburg, Germany aut NATIONALLICENCE 700 1- Sugarbaker Paul Washington Cancer Institute, Columbia, Washington, DC, USA aut NATIONALLICENCE 700 1- Hayes-Jordan Andrea MD Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Facy Audrey University Hospital of Dijon, Dijon, France aut NATIONALLICENCE 700 1- Bakrin Naoual University Hospital of Lyon South, Pierre Bénite, France aut NATIONALLICENCE 700 1- Rat Patrick INSERM UMR 866, Dijon, France aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2297-2301 1068-9265 18:8<2297 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer