caa a22 4500 445336455 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1614-6 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1614-6 Prognostic Value of Lymph Node Density in Node-Positive Patients with Oral Squamous Cell Carcinoma [Elektronische Daten] [Sang Kim, Soon Nam, Seung-Ho Choi, Kyung-Ja Cho, Jong-Lyel Roh] Background: Lymph node density (LND) is superior to TNM nodal status in predicting survival after surgery for bladder and other cancers. Little is known, however, about whether LND can predict survival in patients with oral squamous cell carcinoma (OSCC). We therefore evaluated the utility of LND for predicting survival for patients with OSCC and positive nodes (pN+). Methods: We reviewed the clinical, pathologic, and follow-up data of 211 OSCC patients who underwent surgery. All lymph nodes harvested from neck dissection were carefully examined, with LND calculated as the ratio of positive lymph nodes to total lymph nodes removed. Univariate and multivariate analyses of variables predicting overall survival (OS) and disease-specific survival (DSS) were performed for all patients and in pN+ patients. Results: Kaplan-Meier analyses showed that the 5-year OS and DSS rates in all patients were 72% and 79%, respectively. Multivariate analysis showed that variables independently prognostic for DSS were T classification (hazard ratio [HR]=2.97, 95% confidence interval [95% CI]=1.59-5.57; P=.001), and N classification (HR=4.91, 95% CI=2.47-9.75; P<.001). In pN+ patients, univariate analysis showed that T classification, >2 positive nodes, and LND >0.06 (median) were significant predictors of DSS (P<.015 each), and multivariate analysis showed that LND was an independent predictor of DSS (HR=3.24, 95% CI=1.61-6.53; P=.001). Conclusions: LND may be useful in stratifying the likelihood of survival in patients with OSCC. Society of Surgical Oncology, 2011 Kim Sang Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Nam Soon Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Choi Seung-Ho Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Cho Kyung-Ja Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Roh Jong-Lyel Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2310-2317 1068-9265 18:8<2310 2011 18 10434 https://doi.org/10.1245/s10434-011-1614-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1614-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Sang Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Nam Soon Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Seung-Ho Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Cho Kyung-Ja Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Roh Jong-Lyel Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2310-2317 1068-9265 18:8<2310 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer