caa a22 4500 445336536 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1742-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1742-z Retroperitoneal Sarcoma: Is It Time to Change the Surgical Policy? [Elektronische Daten] [Chiara Mussi, Piergiuseppe Colombo, Alexia Bertuzzi, Massimiliano Coladonato, Pietro Bagnoli, Simona Secondino, Pierina Navarria, Emanuela Morenghi, Armando Santoro, Vittorio Quagliuolo] Background: Complete tumor resection is the mainstay of treatment for retroperitoneal sarcoma (RPS), but the size and quality of surgical margins for radical resection in RPS are unknown. They are believed to be pushing tumors, but recently, aggressive surgical policies leading to multivisceral resection have seemed to suggest better local control compared with simple tumor resection. We analyzed a single-institution series of RPS to provide information useful to surgical decision-making. Methods: From 1996 to 2008, 77 patients referred to our institution underwent surgery for primary RPS. Thirty tumors were classified as liposarcoma, and 20 as leiomyosarcoma. Potential prognostic factors were tested retrospectively. Number and pathologic status of resected organs were assessed. Results: 151 organs were resected. Ninety-two were involved by the tumor (60.9%). Liposarcoma involved 48 of 77 organs resected for this histotype (62.3%). Infiltrative pattern was observed in 39/92 organs, and expansive pattern in 53/92 viscera. The infiltrative pattern was more often observed in leiomyosarcoma and non-lipogenic tumors. The expansive pattern was more often observed in liposarcoma. Psoas was the organ most often involved by infiltrative pattern (12/14); the kidney was the organ most often involved by expansive pattern (19/28). 80% of patients had at least one viscera infiltrated by the tumor. Conclusions: This series, in which an aggressive surgical policy was adopted along with extensive pathologic sampling, shows that RPS has a high rate of viscera infiltration. This growth pattern is characteristic of well-differentiated liposarcoma too. These pathologic data should be considered when planning surgical strategy. Society of Surgical Oncology, 2011 Mussi Chiara Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Colombo Piergiuseppe Pathology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Bertuzzi Alexia Medical Oncology and Hematology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Coladonato Massimiliano Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Bagnoli Pietro Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Secondino Simona Medical Oncology and Hematology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Navarria Pierina Radiotherapy Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Morenghi Emanuela Department of Biostatistics, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Santoro Armando Medical Oncology and Hematology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Quagliuolo Vittorio Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2136-2142 1068-9265 18:8<2136 2011 18 10434 https://doi.org/10.1245/s10434-011-1742-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1742-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mussi Chiara Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Colombo Piergiuseppe Pathology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Bertuzzi Alexia Medical Oncology and Hematology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Coladonato Massimiliano Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Bagnoli Pietro Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Secondino Simona Medical Oncology and Hematology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Navarria Pierina Radiotherapy Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Morenghi Emanuela Department of Biostatistics, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Santoro Armando Medical Oncology and Hematology Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 700 1- Quagliuolo Vittorio Sarcoma Unit, Surgical Department, Istituto Clinico Humanitas, University of Milan School of Medicine, Rozzano (Milan), Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2136-2142 1068-9265 18:8<2136 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer